VEGF as a Potential Candidate for Developing Novel Therapy and Diagnosis for MODS in Sepsis: Development of microcirculation-based therapeutic and diagnostic approach in sepsis

我们前瞻性地研究了(1)血管生成因子及其可溶性受体与器官功能障碍的关系；(2)弥散性血管内凝血（DIC）诱导的血小板消耗、凝血酶生成和组织缺氧对这些因子和受体表达的影响。50例脓毒症患者分为两个亚组：37例DIC患者和13例非DIC患者。我们发现，VEGF、sVEGFR1、Ang2和Ang1/Ang2，特别是Ang2，可能在DIC相关脓毒症中MODS的发生中起作用，并且VEGF、sVEGFR1和Ang2血清水平与DIC诱导的血小板消耗程度、凝血酶生成和血乳酸水平相关。

We prospectively studied(1) the relationships between angiogenic factors, their soluble receptors and organ dysfunction and(2) the effects of disseminated intravascular coagulation (DIC)-induced platelet consumption, thrombin generation, and tissue hypoxia on the expression of the factors and receptorsFifty patients with sepsis were classified into two subgroups: 37 patients with DIC and 13 patients without DIC. We found, VEGF, sVEGFR1, Ang2, and Ang1/Ang2, especially Ang2, may have roles in the development of MODS in sepsis associated with DIC, and VEGF, sVEGFR1, and Ang2 serum levels correlated with the extent of DIC-induced platelet consumption, thrombin generation, and blood lactate levels.