VEGF as a Potential Candidate for Developing Novel Therapy and Diagnosis for MODS in Sepsis: Development of microcirculation-based therapeutic and diagnostic approach in sepsis

VEGF 作为开发脓毒症 MODS 新疗法和诊断的潜在候选者：开发基于微循环的脓毒症治疗和诊断方法

• 批准号: 23792095
• 负责人: JESMIN Subrina
• 金额: $ 2.75万
• 依托单位: University of Tsukuba (2012)Research Institute, International Medical Center of Japan (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792095/
• 关键词: 敗血症; 多臓器障害; VEGF; 微小循環異常; Sepsis; ALI/ARDS; microcirculation; VEGF signaling; therapeutic options; Lipopolysaccharide

We prospectively studied(1) the relationships between angiogenic factors, their soluble receptors and organ dysfunction and(2) the effects of disseminated intravascular coagulation (DIC)-induced platelet consumption, thrombin generation, and tissue hypoxia on the expression of the factors and receptorsFifty patients with sepsis were classified into two subgroups: 37 patients with DIC and 13 patients without DIC. We found, VEGF, sVEGFR1, Ang2, and Ang1/Ang2, especially Ang2, may have roles in the development of MODS in sepsis associated with DIC, and VEGF, sVEGFR1, and Ang2 serum levels correlated with the extent of DIC-induced platelet consumption, thrombin generation, and blood lactate levels.

我们前瞻性研究了血管生成因子及其可溶性受体与器官功能障碍的关系，以及弥散性血管内凝血（DIC）诱导的血小板消耗、凝血酶生成和组织缺氧对血管生成因子及其可溶性受体表达的影响。我们发现，VEGF，sVEGFR 1，Ang 2，Ang 1/Ang 2，特别是Ang 2，可能在DIC相关的脓毒症MODS的发展中起作用，并且VEGF，sVEGFR 1和Ang 2血清水平与DIC诱导的血小板消耗，凝血酶生成和血乳酸水平的程度相关。

项目成果

The relationship between the angiogenic factors and coagulofibrinolysis in trauma patients

创伤患者血管生成因子与凝血纤溶的关系

• 发表时间: 2011
• 作者: Jesmin S;et al
• 通讯作者: et al

The relationship between the expression of vascular endothelial growth factor and coagulofibrinolysis in trauma patients

创伤患者血管内皮生长因子表达与凝血纤溶的关系

• 发表时间: 2011
• 作者: Wada T;Jesmin S;Gando S
• 通讯作者: Gando S

CN. MOWA. Actaea racemosa (black cohosh) hydroethanolic extract alters LPS-induced expression of pro- and anti-inflammatory factors in the cervix of ovariectomized mice.

CN.

• 发表时间: 2011
• 作者: N. Diggins;J. McCoy;G. Hou;C. Okunji;S. Jesmin
• 通讯作者: S. Jesmin

Time dependent alterations of VEGF and its signal in molecules in acute lung injury in a rat model of sepsis.

脓毒症大鼠模型急性肺损伤中 VEGF 及其分子信号的时间依赖性变化。

• 发表时间: 2011
• 作者: T Wada;S. Jesmin;S. Zaedi;S Gando
• 通讯作者: S Gando

Time-dependent expression of endotheline-1 in lungs and the effects of TNF-α blocking peptide on entodhelin-1 levels in lungs in endotoxemic rat model.

内毒素血症大鼠模型中肺内皮素 1 的时间依赖性表达以及 TNF-α 阻断肽对肺内内皮素 1 水平的影响。

• 发表时间: 2011
• 作者: S. Jesmin;T. Wada;S. Zaedi;SN Suhana;Y Yamagushi;A Iwashima;S Gando
• 通讯作者: S Gando