Elucidating the molecular mechanism of a peptide, SCRG1, derived from mesenchymal stem cells to suppress the osteoclast differentiation.

阐明源自间充质干细胞的肽 SCRG1 抑制破骨细胞分化的分子机制。

• 批准号: 25463224
• 负责人: Takahashi Noriko
• 金额: $ 3.16万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25463224/
• 关键词: 歯周組織再生; 炎症抑制; 炎症性サイトカイン; 炎症性骨吸収; 間葉系幹細胞; SCRG1; 破骨細胞; 分化

项目成果

Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.

• DOI: 10.1038/srep03652
• 发表时间: 2014-01-13
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Aomatsu E;Takahashi N;Sawada S;Okubo N;Hasegawa T;Taira M;Miura H;Ishisaki A;Chosa N
• 通讯作者: Chosa N

VEGF-C and TGF-β reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes.

VEGF-C和TGF-β相互调节间充质干细胞对分化为淋巴内皮或成骨细胞表型的承诺。

• DOI: 10.3892/ijmm.2016.2502
• 发表时间: 2016-04
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: Igarashi Y;Chosa N;Sawada S;Kondo H;Yaegashi T;Ishisaki A
• 通讯作者: Ishisaki A

Zoledronic acid suppresses transforming growth factor-β (TGF-β)-induced fibrogenesis by human gingival fibroblasts possibly through down-regulation of TGF-β type I receptor expression

唑来膦酸可能通过下调 TGF-β I 型受体表达来抑制转化生长因子-β (TGF-β) 诱导的人牙龈成纤维细胞纤维化

• 发表时间: 2016
• 期刊: International Journal of Molecular Medicine
• 影响因子: 5.4
• 作者: Komatsu Y.;Ibi M.;Chosa N.;Kyakumoto S.;Kamo M.;Shibata T.;Sugiyama Y.;Ishisaki A.
• 通讯作者: Ishisaki A.

Establishment of immortalized mesenchymal stem cells derived from the submandibular glands of tdTomato transgenic mice.

• DOI: 10.3892/etm.2015.2700
• 发表时间: 2015-10
• 期刊: Experimental and therapeutic medicine
• 影响因子: 2.7
• 作者: Furukawa S;Kuwajima Y;Chosa N;Satoh K;Ohtsuka M;Miura H;Kimura M;Inoko H;Ishisaki A;Fujimura A;Miura H
• 通讯作者: Miura H

Re-examination of a α-chymotrypsin-solubilized laccase in the pupal cuticle of the silkworm, Bombyx mori: Insights into the regulation system for laccase activation during the ecdysis process

• DOI: 10.1016/j.ibmb.2014.10.004
• 发表时间: 2014-12-01
• 期刊: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
• 影响因子: 3.8
• 作者: Asano, Tsunaki;Taoka, Masato;Chosa, Naoyuki
• 通讯作者: Chosa, Naoyuki