Understanding the role of miRNAs in the biology of ageing muscle

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Skeletal muscle is the largest organ in the body and plays a vital role in maintaining independent living and social interaction. As it ages, skeletal muscle loses its ability to build up new muscle proteins. However, the principles underlying the biology of skeletal muscle ageing are not well understood. MicroRNAs (MiRNAs) are essential regulators of skeletal muscle biology. Whether they play a role in the ageing process and how they regulate muscle protein synthesis as we age has not been investigated. This project aims to identify the MiRNA species involved in muscle protein synthesis and will provide a better understanding of the biology of ageing skeletal muscle.