Understanding the determinants of age-related muscle wasting in females

了解女性年龄相关肌肉萎缩的决定因素

• 批准号: FT210100278
• 负责人: A/Prof Severine Lamon
• 金额: $ 66.6万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT210100278
• 关键词: Understanding; determinants; age; related; muscle

This project aims to investigate the fundamental mechanisms underlying age-related muscle wasting in females. Females live longer than males and are more susceptible to the consequences of muscle ageing. Yet, our current knowledge is overwhelmingly inferred from findings from male cohorts. By comprehensively mapping the functional, molecular and epigenetic mechanisms of ageing in female muscle, this project will generate new, fundamental knowledge that will allow a unique interpretation of previous research through a sex-specific lens. This knowledge will contribute to better inform sex-specific models of research and practice in the future, ultimately delivering economic and social benefits for Australia and international communities.

本项目旨在研究女性年龄相关性肌肉萎缩的基本机制。女性比男性寿命长，更容易受到肌肉老化的影响。然而，我们目前的知识绝大多数是从男性群体的发现中推断出来的。通过全面绘制女性肌肉衰老的功能、分子和表观遗传机制，该项目将产生新的基础知识，通过性别特异性透镜对以前的研究进行独特的解释。这些知识将有助于在未来更好地为针对性别的研究和实践模式提供信息，最终为澳大利亚和国际社会带来经济和社会效益。