Comprehensive analysis of the origin of colorectal cancer based on intratumoral genetic heterogeneity

基于瘤内遗传异质性的结直肠癌起源综合分析

• 批准号: 25860547
• 负责人: YAMAMOTO Eiichiro
• 金额: $ 2.66万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860547/
• 关键词: 大腸がん; 遺伝子変異; メチル化; 大腸癌

项目成果

Histone H3K27 trimethylation in normal colon is associated with developing colorectal tumor with CpG island methylator phenotype

正常结肠中的组蛋白 H3K27 三甲基化与具有 CpG 岛甲基化表型的结直肠肿瘤的发展相关

• 发表时间: 2014
• 作者: Suzuki R1;Yamamoto E;Nojima M;Maruyama R;Yamano HO;Yoshikawa K;Kimura T;Harada T;Ashida M;Niinuma T;Sato A;Nosho K;Yamamoto H;Kai M;Sugai T;Imai K;Suzuki H;Shinomura Y.;Eiichiro Yamamoto;Eiichiro Yamamoto
• 通讯作者: Eiichiro Yamamoto

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

• DOI: 10.1053/j.gastro.2013.10.060
• 发表时间: 2014-02
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Tahara T;Yamamoto E;Madireddi P;Suzuki H;Maruyama R;Chung W;Garriga J;Jelinek J;Yamano HO;Sugai T;Kondo Y;Toyota M;Issa JP;Estécio MR
• 通讯作者: Estécio MR

Intratumoral variation in surface microstructures reflects genetic heterogeneity revealed by exome sequencing of colorectal tumor.

表面微结构的瘤内变化反映了结直肠肿瘤外显子组测序揭示的遗传异质性。

• 作者: Suzuki R1;Yamamoto E;Nojima M;Maruyama R;Yamano HO;Yoshikawa K;Kimura T;Harada T;Ashida M;Niinuma T;Sato A;Nosho K;Yamamoto H;Kai M;Sugai T;Imai K;Suzuki H;Shinomura Y.;Eiichiro Yamamoto;Eiichiro Yamamoto;Eiichiro Yamamoto
• 通讯作者: Eiichiro Yamamoto

Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk.

• DOI: 10.1007/s00535-013-0861-7
• 发表时间: 2014-07
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Suzuki, Ryo;Yamamoto, Eiichiro;Nojima, Masanori;Maruyama, Reo;Yamano, Hiro-o;Yoshikawa, Kenjiro;Kimura, Tomoaki;Harada, Taku;Ashida, Masami;Niinuma, Takeshi;Sato, Akiko;Nosho, Katsuhiko;Yamamoto, Hiroyuki;Kai, Masahiro;Sugai, Tamotsu;Imai, Kohzoh;Suzuki, Hiromu;Shinomura, Yasuhisa
• 通讯作者: Shinomura, Yasuhisa

INTRATUMORAL VARIATIONS IN PIT PATTERNS REFLECT GENETIC HETEROGENEITY REVEALED BY HIGH- THROUGHPUT SEQUENCING OF COLORECTAL TUMOR

瘤内凹坑模式的变化反映了结直肠肿瘤高通量测序揭示的遗传异质性

• 作者: Suzuki R1;Yamamoto E;Nojima M;Maruyama R;Yamano HO;Yoshikawa K;Kimura T;Harada T;Ashida M;Niinuma T;Sato A;Nosho K;Yamamoto H;Kai M;Sugai T;Imai K;Suzuki H;Shinomura Y.;Eiichiro Yamamoto;Eiichiro Yamamoto;Eiichiro Yamamoto;Eiichiro Yamamoto
• 通讯作者: Eiichiro Yamamoto