Biological function of Egr-1 in the nervous system

Egr-1在神经系统中的生物学功能

• 批准号: 5436911
• 负责人: Professor Dr. Gerald Thiel
• 金额: --
• 依托单位: Arbeitsgruppe Thiel - Gene Expression and Signal Transduction Laboratory
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2004-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5436911?language=en
• 关键词: Biological; function; Egr; nervous; system

The biosynthesis of the zinc finger transcription factor Egr-1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The Egr-1 gene therfore functions as a convergence point for many signaling cascades. The Egr-1 protein links these cellular signaling cascades with changes in the gene expression pattern of Egr-1-responsive target genes. Many biological functions have been attributed to Egr-1, including the control of cellular proliferation and programmed cell death. Using transgenic mice containing a disrupted Egr-1 gene, we plan to analyze the biological functions of Egr-1 in the nervous system. The investigation will be focused on the elucidation of the role that Egr-1 plays in the control of astrocyte proliferation and neuronal programmed cell death.

锌指转录因子Egr-1的生物合成受到许多细胞外信号分子的刺激，包括激素、神经递质、生长和分化因子以及细胞毒性代谢物。因此，Egr-1基因作为许多信号级联的汇聚点发挥作用。Egr-1蛋白将这些细胞信号级联与Egr-1应答靶基因的基因表达模式的变化联系起来。许多生物学功能已归因于Egr-1，包括控制细胞增殖和程序性细胞死亡。我们计划使用含有Egr-1基因破坏的转基因小鼠，分析Egr-1在神经系统中的生物学功能。本研究的重点是阐明Egr-1在控制星形胶质细胞增殖和神经元程序性细胞死亡中的作用。