A therapeutic strategy for malignant mesothelioma with reconstituting tumor suppressor pathways which were defective due to the characteristic genetic deletion

通过重建因特征性基因缺失而存在缺陷的肿瘤抑制途径来治疗恶性间皮瘤

• 批准号: 16K09598
• 负责人: Shingyoji Masato
• 金额: $ 3万
• 依托单位: Chiba Cancer Center (Research Institute)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09598/
• 关键词: 悪性中皮腫; p53経路; Hippo経路; 細胞障害活性; アデノウイルス; MDM2阻害剤; MDM2; FAK; 低分子G蛋白; AMPK-mTOR; 細胞死; MDM4; NF2; Rb蛋白; Mdm2; Mdm4; ユビキチン化; 遺伝子; トランスレーショナルリサーチ; バイオテクノロジー

项目成果

Combination of nutlin-3a and HSP90 inhibitors produces synergistic cytotoxicity on mesothelioma with the wild-type p53

nutlin-3a 和 HSP90 抑制剂的组合与野生型 p53 对间皮瘤产生协同细胞毒性

• 发表时间: 2016
• 作者: Masatoshi Tagawa;Shinya Okamoto;Takao Morinaga;Masato Shingyoji;Ikuo Sekine;Toshio Suzuki;Yuji Tada;Koichiro Tatsumi;Hideaki Shimada;Kenzo Hiroshima
• 通讯作者: Kenzo Hiroshima

An MDM2 inhibitor achieves synergistic cytotoxicity with oncolytic adenoviruses on mesothelioma with the wild-type p53 gene

MDM2 抑制剂与溶瘤腺病毒对野生型 p53 基因的间皮瘤实现协同细胞毒性

• 发表时间: 2018
• 作者: Masatoshi Tagawa;Thao Thi Thanh Nguyen;Takao Morinaga;Masato Shingyoji;Yuji Tada;Koichiro Tatsumi;Hideaki Shimada;Kenzo Hiroshima
• 通讯作者: Kenzo Hiroshima

A MDM2 inhibitor augments cytotoxicity of oncolytic adenoviruses defective of E1B 55kDa molecules through enhancing DNA damages and apoptosis in mesothelioma

MDM2 抑制剂通过增强间皮瘤中的 DNA 损伤和细胞凋亡来增强 E1B 55kDa 分子缺陷的溶瘤腺病毒的细胞毒性

• 发表时间: 2017
• 作者: Masatoshi Tagawa;Thao Thi Thanh Nguyen;Takao Morinaga;Boya Zhong;Michiko Hanazono;Shuji Kubo;Masato Shingyoji;Yuji Tada;Koichiro Tatsumi;Hideaki Shimada;Kenzo Hiroshima
• 通讯作者: Kenzo Hiroshima

An inhibitor for the MDM2-p53 Interaction Produces Synergistic Cytotoxicity with Oncolytic Adenoviruses on Mesothelioma with Wild-type p53 Genotype

MDM2-p53 相互作用抑制剂与溶瘤腺病毒对野生型 p53 基因型间皮瘤产生协同细胞毒性

• 发表时间: 2017
• 作者: Masatoshi Tagawa;Thao Thi Thanh Nguyen;Takao Morinaga;Boya Zhong;Michiko Hanazono;Shuji Kubo;Masato Shingyoji;Yuji Tada;Koichiro Tatsumi;Hideaki Shimada;Kenzo Hiroshima
• 通讯作者: Kenzo Hiroshima

Cytotoxicity of Replication-Competent Adenoviruses Defective of E1B55kDa Molecules Is Irrelevant to P53 Expression, but Increases with a P53-Augmenting MDM2 Inhibitor through DNA Damages and Enhanced Viral Propagations in Mesothelioma with the Wild-Type P

E1B55kDa 分子缺陷的具有复制能力的腺病毒的细胞毒性与 P53 表达无关，但通过 P53 增强 MDM2 抑制剂通过 DNA 损伤和增强野生型 P 间皮瘤中的病毒传播而增加细胞毒性

• 发表时间: 2018
• 作者: Thao Thi Thanh Nguyen;Takao Morinaga;Boya Zhong;Shuji Kubo;Masato Shingyoji;Yuji Tada;Yuichi Takiguchi;Koichiro Tatsumi;Hideaki Shimada;Kenzo Hiroshima;Masatoshi Tagawa
• 通讯作者: Masatoshi Tagawa