Identification of blood biomarkers predicting clinical efficacy of molecular targeting agents in multiple myeloma

预测分子靶向药物在多发性骨髓瘤中临床疗效的血液生物标志物的鉴定

• 批准号: 16K09855
• 负责人: Iida Shinsuke
• 金额: $ 3万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09855/
• 关键词: 多発性骨髄腫; 分子標的薬; バイオマーカー; マイクロRNA; セルフリーDNA; 脂質; 血液; 病態進展; 血液中バイオマーカー; cell free DNA; 脂質メタボロミクス; ボルテゾミブ; 臨床効果; 末梢神経障害; リキッドバイオプシー; microRNA; 脂質メタボローム; 効果予測; miRNA; 脂質メタボローム解析; エキソソーム; 遊離核酸; 医療; トランスレーショナルリサーチ; 骨髄腫

项目成果

Plasma cell myeloma positive for t(14;20) with relapse in the central nervous system

t(14;20) 阳性浆细胞骨髓瘤伴中枢神经系统复发

• DOI: 10.3960/jslrt.19011
• 发表时间: 2019
• 期刊: Journal of Clinical and Experimental Hematopathology
• 影响因子: 1.5
• 作者: Murase Takayuki;Inagaki Atsushi;Masaki Ayako;Fujii Keiichiro;Narita Tomoko;Ri Masaki;Hanamura Ichiro;Iida Shinsuke;Inagaki Hiroshi
• 通讯作者: Inagaki Hiroshi

Comprehensive genetic analysis of multiple myeloma in Japan

日本多发性骨髓瘤的综合遗传分析

• 发表时间: 2019
• 作者: Kanamori T;Sanada M;Ri M;Ueno H;Nishijima D;Yasuda T;Aoki S;Asano A;Tachita T;Kinoshita S;Narita T;Ito A;Kusumoto S;Masuda Y;Kobayashi N;Shiozawa Y;Yoshida K;Nakagawa M;Nannya Y;Shiraishi Y;Chiba K;Tanaka H;Komatsu H;Miyano S;Handa
• 通讯作者: Handa

Immunohistochemistry for identification ofCCND1,NSD2, andMAFgene rearrangements in plasma cell myeloma

免疫组织化学鉴定浆细胞骨髓瘤中 CCND1、NSD2 和 MAF 基因重排

• DOI: 10.1111/cas.14109
• 发表时间: 2019
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Murase Takayuki;Ri Masaki;Narita Tomoko;Fujii Keiichiro;Masaki Ayako;Iida Shinsuke;Inagaki Hiroshi
• 通讯作者: Inagaki Hiroshi

Analysis of expression levels, mutations, and methylation status of CRBN-related genes pre- and post-lenalidomide treatment in multiple myeloma

多发性骨髓瘤来那度胺治疗前后CRBN相关基因的表达水平、突变和甲基化状态分析

• 发表时间: 2019
• 作者: Tachita T;Kinoshita S;Ri M;Aoki S;Asano A;Kanamori T;Totani H;Asao Y;Narita T;Ito A;Kusumoto S;Komatsu H;Iida S
• 通讯作者: Iida S

1.Lipidomic profiling of plasma samples in patients with newly diagnosed multiple myeloma; a biomarker study for predicting the response and toxicity of Melphalan, Prednisolone, and Bortezomib (MPB) regimen: an ancillary study of JCOG1105 (JCOG1105A1)

1.新诊断多发性骨髓瘤患者血浆样本的脂质组学分析；

• 发表时间: 2019
• 作者: Masaki Ri;Shinsuke Iida;Dai Maruyama;Kosuke Saito;Yoshiro Saito;Satoshi Osaga;Masahiro Tohkin;Naoki Miyata;Noriko Fukuhara;Kana Miyazaki;Norifumi Tsukamoto;Hideki Tsujimura;Makoto Yoshimitsu;Kenichi Miyamoto;Kunihiro Tsukasaki;and Hirokazu
• 通讯作者: and Hirokazu