Neuronal Population Dynamics of the Cerebral Cortex underlying Spontaneous Volitional Behaviors

自发意志行为背后的大脑皮层神经元群动态

• 批准号: 16J10077
• 负责人: LEE RAY XIN
• 金额: $ 1.79万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-22 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J10077/
• 关键词: Stress incubation; PTSD; Comparative psychology; Cumulative distribution; Social relationship; Calcium imaging; Automatic image analysis; Manifold learning; stress incubation; comparative psychology; cumulative distribution; social relationship

In FY2018, I continued to address behavior project to respond to journal peer-review. First, I reduced the connection to human PTSD and instead focus on the development of stress incubation in mice through social witnessing. Second, I reported the results from three new experiments (Stranger-buffered, Environment-enriched, and FLX-treated groups) and two new tests (plasma corticosterone concentration test and diffusion tensor imaging). Finally, I included a more clearly articulated theoretical framework as well as an expanded discussion.I was invited to present its disruptive innovation that impacts the foundation of classic logic in understanding animal emotion at a TEDx talk (October 13, 2018) to public. Lately, on this topic, I was awarded the Young Investigator Award of the Japanese Society for Behavioral Neuroendocrinology, University of Tsukuba (March 21, 2019) and the 1st place of the poster competition at the 3rd Sino-Japan Workshop on the Frontier of Behavioral Neuroendocrinology, University of Tsukuba (March 21, 2019).For the imaging project, I used machine learning algorithms to predict behavior from neuronal activity, and vice versa, for the last part of control tests before the paper submission. On this topic, I was invited to present the results at ICIIBMS 2018 conference (October 23, 2018), University College London (Mar 7, 2019), and Princeton Neuroscience Institute (April 10, 2019). For both topics, I also completed my thesis and defended my PhD successfully.

在2018财年，我继续处理行为项目，以回应期刊同行审查。首先，我减少了与人类创伤后应激障碍的联系，转而专注于通过社会见证在小鼠身上孕育压力的发展。其次，我报告了三个新的实验(Stranger-Buffed，Environment-Enhated，和Flx处理组)和两个新的测试(血浆皮质酮浓度测试和扩散张量成像)的结果。最后，我包括了一个更清晰的理论框架以及更广泛的讨论。我应邀在TEDx演讲(2018年10月13日)上向公众介绍了其颠覆性创新，该创新影响了理解动物情感的经典逻辑的基础。最近，在这个话题上，我获得了筑波大学日本行为神经内分泌学学会青年研究员奖(2019年3月21日)和筑波大学第三届中日行为神经内分泌学前沿研讨会海报竞赛第一名(2019年3月21日)。在成像项目中，我使用机器学习算法根据神经元活动预测行为，反之亦然，在论文提交前的最后一部分控制测试中。关于这个话题，我应邀在ICIIBMS 2018年会议(2018年10月23日)、伦敦大学学院(2019年3月7日)和普林斯顿神经科学研究所(2019年4月10日)上发表了研究成果。对于这两个主题，我也完成了我的论文，并成功地捍卫了我的博士学位。

项目成果

Detection and identification of animal emotionality-exposing stress incubation in Mice

小鼠情绪暴露应激孵化的检测和鉴定

• DOI: 10.1109/iciibms.2017.8279754
• 发表时间: 2017
• 期刊: 2017 International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS)
• 作者: B. Kuhn;Ray X. Lee;G. Stephens
• 通讯作者: G. Stephens

Computational behavioral analysis of acute psychosocial trauma reveals gradually increasing stress reactions in adult mice

急性心理社会创伤的计算行为分析揭示成年小鼠的应激反应逐渐增加

• 发表时间: 2017
• 作者: Lee R. X.;Stephens G. J.;& Kuhn B
• 通讯作者: & Kuhn B

TEDx talk

TEDx 演讲

ICIIBMS abstract

ICIIBMS摘要

Poster presentation in CNS*2017

CNS*2017 海报展示