Establishing a rapid and highly efficient method for in vivo direct reprogramming of fibroblasts into epithelial lineages using mesenchymal-to-epithelial transition program(Fostering Joint International Research)

利用间充质到上皮转化程序建立一种快速高效的方法，将成纤维细胞体内直接重编程为上皮谱系（促进国际联合研究）

• 批准号: 16KK0165
• 负责人: Watanabe Kazuhide
• 金额: $ 9.73万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Fund for the Promotion of Joint International Research (Fostering Joint International Research)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017 至 2022
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16KK0165/
• 关键词: 生体内リプログラミング; 間葉上皮移行; 転写因子; OVOL2; 表皮細胞; エピゲノム; 上皮間葉転換; 間葉上皮転換; in vivo reprogramming; 再生医学; バイオテクノロジー

项目成果

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1.

• DOI: 10.1016/j.celrep.2021.110240
• 发表时间: 2022-01-11
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Han Y;Villarreal-Ponce A;Gutierrez G Jr;Nguyen Q;Sun P;Wu T;Sui B;Berx G;Brabletz T;Kessenbrock K;Zeng YA;Watanabe K;Dai X
• 通讯作者: Dai X

University of California, Irvine(米国)

加州大学欧文分校（美国）

Comparative single-cell transcriptomes of dose and time dependent epithelial-mesenchymal spectrums.

• DOI: 10.1093/nargab/lqac072
• 发表时间: 2022-09
• 期刊: NAR GENOMICS AND BIOINFORMATICS
• 影响因子: 4.6
• 作者: Panchy, Nicholas;Watanabe, Kazuhide;Takahashi, Masataka;Willems, Andrew;Hong, Tian
• 通讯作者: Hong, Tian

Effective pseudo-labeling based on heatmap for unsupervised domain adaptation in cell detection

• DOI: 10.1016/j.media.2022.102436
• 发表时间: 2022-04
• 期刊: Medical image analysis
• 影响因子: 10.9
• 作者: Hyeonwoo Cho;Kazuya Nishimura;Kazuhide Watanabe;Ryoma Bise