Restoration of inner ear gap junction with iPS derived model cell and genome editing

使用 iPS 衍生模型细胞和基因组编辑恢复内耳间隙连接

• 批准号: 17H04348
• 负责人: Ikeda Katsuhisa
• 金额: $ 10.9万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04348/
• 关键词: 遺伝性難聴; iPS細胞; ギャップ結合; GJB2; ゲノム編集; 内耳; 遺伝子改変動物

项目成果

Age-stratified sex differences in polysomnographic findings and pharyngeal morphology among children with obstructive sleep apnea

• DOI: 10.21037/jtd.2018.11.09
• 发表时间: 2018-12-01
• 期刊: JOURNAL OF THORACIC DISEASE
• 影响因子: 2.5
• 作者: Inoshita, Ayako;Kasai, Takatoshi;Ikeda, Katsuhisa
• 通讯作者: Ikeda, Katsuhisa

Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation

• DOI: 10.1016/j.jaci.2018.10.034
• 发表时间: 2019-03-01
• 期刊: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
• 影响因子: 14.2
• 作者: Takamori, Ayako;Izawa, Kumi;Kitaura, Jiro
• 通讯作者: Kitaura, Jiro

Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation

从携带 GJB2 (p.V37I) 突变的听力损失患者中产生诱导多能干细胞 (hiPSC) 系 (JUFMDOi004-A)

• DOI: 10.1016/j.scr.2019.101674
• 发表时间: 2020
• 期刊: Stem Cell Research
• 影响因子: 1.2
• 作者: Fukunaga Ichiro;Shiga Takahiro;Chen Cheng;Oe Yoko;Danzaki Keiko;Ohta Sayaka;Matsuoka Rina;Anzai Takashi;Hibiya-Motegi Remi;Tajima Shori;Ikeda Katsuhisa;Akamatsu Wado;Kamiya Kazusaku
• 通讯作者: Kamiya Kazusaku

A case of ectopic salivary gland of the larynx.

喉异位唾液腺一例.

• DOI: 10.1016/j.anl.2017.08.001
• 发表时间: 2018
• 期刊: Auris Nasus Larynx
• 影响因子: 1.7
• 作者: Tajima S;Yamauchi K;Higo R;Ikeda K.
• 通讯作者: Ikeda K.

Generation of Functional CX26?Gap‐Junction‐Plaque‐Forming Cells with Spontaneous Ca 2+ Transients via a Gap Junction Characteristic of Developing Cochlea

通过发育中耳蜗的间隙连接特性产生具有自发 Ca 2+ 瞬变的功能性 CX26？间隙连接斑块形成细胞

• DOI: 10.1002/cpsc.100
• 发表时间: 2019
• 期刊: Current Protocols in Stem Cell Biology
• 作者: Fukunaga Ichiro;Fujimoto Ayumi;Hatakeyama Kaori;Kurebayashi Nagomi;Ikeda Katsuhisa;Kamiya Kazusaku
• 通讯作者: Kamiya Kazusaku