Development of biological rhythm adjustment system through eyes for environmental adaptation by integrated analysis of molecule-cell-whole body focused on eye

通过以眼睛为中心的分子-细胞-全身综合分析，开发通过眼睛适应环境的生物节律调节系统

• 批准号: 17H06262
• 负责人: Shigehiro Ohdo
• 金额: $ 16.22万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Research (Pioneering)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-06-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H06262/
• 关键词: 生体リズム; 体内時計; 時計遺伝子; 環境応答; システムバイオロジー; 環境適応

项目成果

Microcurrent stimulation activates the circadian machinery in mice.

微电流刺激激活小鼠的昼夜节律机制。

• DOI: 10.1016/j.bbrc.2019.02.022
• 发表时间: 2019
• 期刊: Biochem Biophys Res Commun.
• 作者: Matsunaga N;Yoshida Y;Kitajou N;Shiraishi A;Kusunose N;Koyanagi S;Ohdo S.
• 通讯作者: Ohdo S.

Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model

• DOI: 10.1016/j.bbrc.2018.05.209
• 发表时间: 2018-09-03
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Akamine, Takahiro;Kusunose, Naoki;Ohdo, Shigehiro
• 通讯作者: Ohdo, Shigehiro

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice

• DOI: 10.1248/bpb.b19-00546
• 发表时间: 2019-11-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Shiromizu, Shoya;Yamauchi, Tomoaki;Ohdo, Shigehiro
• 通讯作者: Ohdo, Shigehiro

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene

• DOI: 10.1074/jbc.ra118.004942
• 发表时间: 2019-01-11
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Katamune, Chiharu;Koyanagi, Satoru;Ohdo, Shigehiro
• 通讯作者: Ohdo, Shigehiro

Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system

• DOI: 10.1016/j.bbrc.2018.06.117
• 发表时间: 2018-09-05
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kimura, Hinako;Matsunaga, Naoya;Ohdo, Shigehiro
• 通讯作者: Ohdo, Shigehiro