Elucidation of immunostimulatory mechanism of IMiDs and antibody-drugs for optimized myeloma treatment

阐明 IMiD 和抗体药物的免疫刺激机制，以优化骨髓瘤治疗

• 批准号: 17K09963
• 负责人: ITO Tomoki
• 金额: $ 3万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09963/
• 关键词: IMiDs; type I IFNs; Th2 immune response; allergy; multiple myeloma; antibody drugs; dendritic cells; CCL17; 樹状細胞; エロツズマブ; カルフィルゾミブ; イキサゾミブ; 多発性骨髄腫; IFN-alpha; IFN-a; Th2; 内科; 免疫学

项目成果

関西医科大学内科学第一講座

关西医科大学内科

Lenalidomide Acts As a Positive Immunomodulator through Modulating the Functions of Human Plasmacytoid Dendritic Cells

来那度胺通过调节人浆细胞样树突状细胞的功能发挥积极的免疫调节剂作用

• 发表时间: 2017
• 作者: Kibata Kayo;Ito Tomoki;Inaba Muneo;Tanaka Akihiro;Iwata Ryoichi;Inagaki-Katashiba Noriko;Phan Vien;Satake Atsushi;Nomura Shosaku;Azuma Y;Azuma Y;Azuma Y;Yoshiko Azuma;Yuta Yamanaka;Yusuke Sawai;Tomoki Ito
• 通讯作者: Tomoki Ito

Clinical troughconcentration of ixazomibdoes not suppressfunction of human dendritic cell subsets

伊沙佐米的临床谷浓度不会抑制人树突状细胞亚群的功能

• 发表时间: 2018
• 作者: Kibata Kayo;Ito Tomoki;Inaba Muneo;Tanaka Akihiro;Iwata Ryoichi;Inagaki-Katashiba Noriko;Phan Vien;Satake Atsushi;Nomura Shosaku;Azuma Y;Azuma Y;Azuma Y;Yoshiko Azuma;Yuta Yamanaka;Yusuke Sawai
• 通讯作者: Yusuke Sawai

The immunomodulatory-drug, lenalidomide, sustains and enhances interferon-α production by human plasmacytoid dendritic cells

免疫调节药物来那度胺可维持并增强人浆细胞样树突状细胞产生干扰素-α

• DOI: 10.2147/jbm.s206459
• 发表时间: 2019
• 期刊: Jounal of Blood Medicine
• 作者: Kibata Kayo;Ito Tomoki;Inaba Muneo;Tanaka Akihiro;Iwata Ryoichi;Inagaki-Katashiba Noriko;Phan Vien;Satake Atsushi;Nomura Shosaku
• 通讯作者: Nomura Shosaku

e: Myeloma cells have the ability to suppress Th1-inducing capacity but enhance Th2-mediated response of dendritic cells by producing factors other than soluble SLAMF7

e：骨髓瘤细胞能够抑制 Th1 诱导能力，但通过产生可溶性 SLAMF7 以外的因子来增强 Th2 介导的树突状细胞反应

• 发表时间: 2018
• 作者: Kibata Kayo;Ito Tomoki;Inaba Muneo;Tanaka Akihiro;Iwata Ryoichi;Inagaki-Katashiba Noriko;Phan Vien;Satake Atsushi;Nomura Shosaku;Azuma Y;Azuma Y;Azuma Y;Yoshiko Azuma
• 通讯作者: Yoshiko Azuma