Aquatic invasion of venomous snakes

毒蛇的水生入侵

• 批准号: DE150101481
• 负责人: Dr Kartik Sunagar
• 金额: --
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE150101481
• 关键词: Aquatic; invasion; venomous; snakes

Animal venoms target multiple physiological pathways to rapidly disrupt homeostasis and cause paralysis and death of prey animals. Physiological protein-encoding genes are recruited into the envenoming function, which then evolve to be highly effective on their molecular targets. The expansion of venom complexity due to the predator-prey chemical 'arms race' has given rise to a plethora of toxin types. While examples of venoms that have become subsequently streamlined and/or simplified in response to a change in environment and/or specialisation of diet are plenty, the underlying mechanisms remain elusive. This project aims to unravel how animal venoms become streamlined and uncover the underexplored vast pharmacopeia of aquatic venoms.

动物毒液针对多种生理途径，迅速破坏体内平衡，导致猎物瘫痪和死亡。生理蛋白质编码基因被招募到环境功能中，然后进化成对它们的分子目标非常有效。由于捕食者和猎物之间的化学“军备竞赛”，毒液的复杂性不断扩大，产生了过多的毒素类型。由于环境的变化和/或饮食的专业化，毒液后来变得精简和/或简化的例子很多，但潜在的机制仍然难以捉摸。该项目旨在揭示动物毒液如何变得流线型，并揭示未被开发的大量水生毒液药典。