Viral capsids as high-efficiency nanoreactors

病毒衣壳作为高效纳米反应器

• 批准号: DP240102772
• 负责人: Prof Till Boecking
• 金额: $ 42.92万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102772
• 关键词: Viral; capsids; efficiency; nanoreactors

This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innovative biophysical techniques for the study of viruses, and an understanding of the engineering principles at play in natural nano-reactors. This project anticipates contributing advanced capabilities in bionanotechnology, benefiting therapeutic, biotechnology and synthetic biology applications.

该项目旨在开发最新的单分子成像，以实时可视化真实逆转录病毒衣壳内的DNA合成。该项目希望通过利用尖端的荧光标签试剂和显微镜技术在病毒学，合成生物学和纳米技术领域中产生新知识。预期的结果包括对逆转录病毒逆转录的全面描述，用于病毒研究的创新生物物理技术的开发以及对天然纳米反应器中发挥作用的工程原理的理解。该项目预计将在Bionanotechnology中贡献高级能力，从而使治疗，生物技术和合成生物学应用受益。