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Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism

Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
平滑肌肌球蛋白突变引起的家族性主动脉夹层的分子机制及血管老化机制的阐明
批准号:
18H02811
负责人:
Nagai Ryozo
金额:
$11.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2018
资助国家:
日本
项目状态:
已结题
起止时间:
2018-04-01 至 2021-03-31

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会议论文
A Deletion Mutation in Myosin Heavy Chain MYH11 Reduces the Contraction Force of the Aorta Resulting in Aortic Dissection
肌球蛋白重链 MYH11 的缺失突变会降低主动脉的收缩力,导致主动脉夹层
DOI: --
发表时间: 2019
期刊:
影响因子: --
作者: [Negishi K, Aizawa K, Imai Y et al.]
通讯作者: Imai Y et al.
Development of a novel PDK4 inhibitor as a new therapeutic agent for heart failure
  • 批准号:
    18K19552
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
  • 资助金额:
    $3.99万
  • 财政年份:
    2018
  • 负责人:
    Nagai Ryozo
  • 依托单位:
Improvement of the PDK4 inhibitors based on the tertiary structure analysis and application for the treatment of heart failure
  • 批准号:
    15K15312
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.33万
  • 财政年份:
    2015
  • 负责人:
    Nagai Ryozo
  • 依托单位:
Protein complex analysis of transcriptional factor KLF, and development of a low molecular weight compound that inhibits KLF5 transcriptional activity.
  • 批准号:
    15H04824
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.23万
  • 财政年份:
    2015
  • 负责人:
    Nagai Ryozo
  • 依托单位:
海外基金