Development of novel therapeutic modality by integrated analysis of immune environment of renal cell carcinoma and remodeling after inhibition of angiogenesis

综合分析肾细胞癌的免疫环境和抑制血管生成后的重塑，开发新的治疗模式

• 批准号: 18H02939
• 负责人: OYA Mototsugu
• 金额: $ 11.15万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02939/
• 关键词: 腎細胞癌; 分子標的治療; 血管新生; 耐性; 免疫治療

项目成果

A comparison of laparoendoscopic single-site surgery versus conventional procedures for laparoscopic donor nephrectomy: a Japanese multi-institutional retrospective study

腹腔镜单部位手术与腹腔镜供肾切除术传统手术的比较：日本多机构回顾性研究

• DOI: 10.1007/s00464-019-07119-9
• 发表时间: 2020
• 期刊: Surgical Endoscopy
• 作者: Shigeta Keisuke;Hasegawa Masanori;Kikuchi Eiji;Yasumizu Yota;Kosaka Takeo;Mizuno Ryuichi;Mikami Shuji;Miyajima Akira;Kufe Donald;Oya Mototsugu;LESS and RPS Research Group in Japanese Society of Endourology
• 通讯作者: LESS and RPS Research Group in Japanese Society of Endourology

The clinical impact of serum C-reactive protein levels in metastatic renal-cell carcinoma patients treated by second-line molecular targeted therapies.

血清 C 反应蛋白水平对二线分子靶向治疗转移性肾细胞癌患者的临床影响。

• 发表时间: 2018
• 作者: Takamatsu K;Mizuno R;Hayakawa N;Kosaka T;Kikuchi E;Mikami S;Oya M
• 通讯作者: Oya M

Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor‐tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma

肿瘤微环境在血管内皮生长因子酪氨酸激酶抑制剂耐药中的意义及透明细胞肾细胞癌全身治疗的最新进展

• DOI: 10.1111/pin.12984
• 发表时间: 2020
• 期刊: Pathology International
• 影响因子: 2.2
• 作者: Mikami Shuji;Mizuno Ryuichi;Kosaka Takeo;Tanaka Nobuyuki;Kuroda Naoto;Nagashima Yoji;Okada Yasunori;Oya Mototsugu
• 通讯作者: Oya Mototsugu

Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm: is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?

• DOI: 10.21037/atm.2019.09.77
• 发表时间: 2019-09
• 期刊: Annals of translational medicine
• 作者: S. Mikami;N. Kuroda;Y. Nagashima;C. Ohe;H. Hayashi;R. Mizuno;M. Oya;K. Kameyama

Real-world use of temsirolimus in Japanese patients with unresectable or metastatic renal cell carcinoma: recent consideration based on the results of a post-marketing, all-case surveillance study

替西罗莫司在日本不可切除或转移性肾细胞癌患者中的实际应用：基于上市后全病例监测研究结果的近期考虑

• DOI: 10.1093/jjco/hyaa062
• 发表时间: 2020
• 期刊: Japanese Journal of Clinical Oncology
• 影响因子: 2.4
• 作者: Sugiyama Shigeru;Sato Kazuo;Shibasaki Yoshiyuki;Endo Yutaka;Uryu Taku;Toyoshima Yasuharu;Oya Mototsugu;Miyanaga Naoto;Saijo Nagahiro;Gemma Akihiko;Akaza Hideyuki
• 通讯作者: Akaza Hideyuki