SPP 1170: Directed Evolution to Optimise and Understand Molecular Biocatalysts

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All cellular reactions are catalysed by proteins (enzymes) or RNAs (ribozymes). Life cannot be understood without understanding how these molecular biocatalysts function and how they are stabilised. Within the Priority Programme the novel approach of directed evolution will be used to generate novel molecular biocatalysts with tailored properties. This will provide new insights into the relationship between sequence, structure and function of enzymes and ribozymes, and help better understanding their natural evolution. Moreover, directed evolution will be used to generate enzymes with useful properties for industrial applications.