SPP 1170: Directed Evolution to Optimise and Understand Molecular Biocatalysts

SPP 1170：优化和理解分子生物催化剂的定向进化

• 批准号: 5472117
• 金额: --
• 依托单位: Lehrstuhl für Biochemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5472117?language=en
• 关键词: SPP; 1170; Directed; Evolution; Optimise

All cellular reactions are catalysed by proteins (enzymes) or RNAs (ribozymes). Life cannot be understood without understanding how these molecular biocatalysts function and how they are stabilised. Within the Priority Programme the novel approach of directed evolution will be used to generate novel molecular biocatalysts with tailored properties. This will provide new insights into the relationship between sequence, structure and function of enzymes and ribozymes, and help better understanding their natural evolution. Moreover, directed evolution will be used to generate enzymes with useful properties for industrial applications.

所有细胞反应都是由蛋白质（酶）或rna（核酶）催化的。如果不了解这些分子生物催化剂是如何起作用以及它们是如何稳定的，就无法理解生命。在优先计划中，定向进化的新方法将用于产生具有定制特性的新型分子生物催化剂。这将对酶和核酶的序列、结构和功能之间的关系提供新的认识，并有助于更好地理解它们的自然进化。此外，定向进化将用于产生具有工业应用有用特性的酶。