SFB 286: Intracellular Transport and Maturation of Proteins

真核细胞的许多膜复合室中的每一个都有一组典型的蛋白质，使其能够发挥其特定的功能。精确运输到正确的细胞器和蛋白质功能所需的成熟过程是合作研究中心的主题。单独的项目研究不同的蛋白质类，它们要么是本土细胞化合物，要么是病毒和原生动物的成分。第一类蛋白质包括膜蛋白。它们是(A)迁移到质膜的蛋白质，(B)并入核膜的蛋白质，以及(C)影响细胞质储存细胞器成分的蛋白质。细胞膜和核膜蛋白来自细胞或病毒，而贮藏细胞器的膜蛋白在植物系统中被研究。第二类蛋白质包括胰腺的分泌蛋白质。第三类是与RNA形成复合体并参与核质运输的蛋白质。

Each one of the many membrane-compounded compartments of the eukaryotic cell possesses a collection of typical proteins that enable it to exert its specific functions. The precise transport to the correct organelle and the maturation processes required for protein function are the subject of the collaborative research centre. Individual projects investigate different protein classes that are either indigenous cellular compounds or components of viruses and protozoa.The first protein class comprises membrane proteins. These are (a)proteins migrating to the plasma membrane, (b) proteins that areincorporated into the nuclear membrane, and (c) proteins that onconstituents of cytoplasmic storage organelles. The plasma membrane and nuclear membrane proteins are of cellular or viral origin, whereas the membrane proteins of storage organelles are investigated in plantsystems. The second protein class comprises secretory proteins of thepancreas. The third class are proteins that form complexes with RNA and are involved in nuclear-cytoplasmic transport.