SFB 466: Lymphoproliferation and viral immunodeficiency

合作研究中心466专注于病毒免疫缺陷和淋巴管肿瘤中造血细胞的控制机制。在分子和结构水平上识别和理解艾滋病的发病机制是一个目标。这个合作研究中心的主题包括病毒效应蛋白、免疫逃避、树突状细胞、HIV特异性细胞毒性T细胞反应和病毒基因的表达。这些项目的共同点是淋巴细胞的激活和生长刺激问题。在每个细胞中，激活、增殖和破坏之间存在着微妙的平衡，这些不同的功能通常通过重叠相同的信号转导途径来调节。合作研究中心的目的是研究淋巴细胞中参与这些过程的基本机制。研究主题是病毒基因产物的细胞凋亡、可控激活和恶性转化。该合作研究中心试图帮助理解淋巴系统中造血细胞的转化和肿瘤的进展。

The collaborative research centre 466 is focussed at the controlmechanism of haematopoetic cells in viral immunodeficiency and lymphatic tumors. It is one goal to identify and understand the mechanisms involved in AIDS pathogenesis at a molecular and structural level. Among the topics of this collaborative research centre are viral effector proteins, immune evasion, dendriticcells, HIV-specific cytotoxic T cell response and expression of viralgenes. The common denominator of the projects is the question ofactivation and growth stimulation of lymphoid cells. There is a delicate balance of activation, proliferation, and destruction in every cell, and these divergent functions are often regulated by overlapping the same signal transduction pathways. It is the aim of the collaborative research centre to investigate the basic mechanism involved in these processes in lymphocytes. The research topics are apoptosis, controlled activation and malignant transformation by viral gene products. The collaborative research centre tries to contribute to the understanding of transformation of haematopoetic cells and tumor progression in the lymphatic systems.