SFB 533: Lichtinduzierte Dynamik von Biopolymeren

合作研究中心533研究生物聚合物的动态过程，特别是蛋白质的构象变化，时间尺度为飞秒至秒。这些过程对它们的功能、折叠以及分子内和分子间的相互作用至关重要。它们包括扰动后的弛豫，以及围绕其平衡点的波动。533合作研究中心专注于光的扰动，因为它们提供了对最快时间尺度的独特访问。与许多蛋白质上众所周知的静态结构相反，我们才刚刚开始了解它们的动态结构，同样，计算处理也非常有限。在2002年结束的第二个供资期内取得的进展同样基于生物化学制备、光谱技术和计算处理方面的进展。我们已经提高了对蛋白质动力学的总体理解，并详细介绍了它们在所选系统中的功能，从而加强了合作研究中心的概念。

The collaborative research centre 533 studies dynamic processes in biopolymers, in particular conformational changes in proteins, on a time-scale of femtoseconds to seconds. These processes are crucial to their function, their folding, and intra- as well as inter-molecular interactions. They include relaxations after perturbations, as well as fluctuations around their equilibria. The collaborative research centre 533 focuses in its work on perturbations by light, because they provide unique access to the fastest time-scales. In contrast to the well-known static structures on many proteins, we are just beginning to understand their dynamic structures and, likewise is the computational treatment very limited. Progress during the second funding period terminating in 2002, is based equally on advances in biochemical preparation, in spectroscopic techniques and in computational treatment. We have improved our general understanding of protein dynamics as well as detailed their functions in the selected systems, thereby strenghtening the concept of the collaborative research centre.