In vitro Germ Cell Differentiation of Cord-Blood-derived Unrestricted Somatic Stem Cells (USSC)

脐带血来源的非限制性成体干细胞 (USSC) 的体外生殖细胞分化

• 批准号: 55928383
• 负责人: Professor Dr. Hans Robert Schöler
• 金额: --
• 依托单位: Klinik für Gastroenterologie, Hepatologie und Endokrinologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/55928383?language=en
• 关键词: vitro; Germ; Cell; Differentiation; Cord

Human cord-blood derived unrestricted somatic stem cells (USSC) can be reprogrammed to induced pluripotent stem (iPS) cells. This project derives and characterizes iPS cells from USSC (iP-USSC) by different means. The differentiation potential of reprogrammed cord blood cells will be assessed in comparison to native USSC. The focus of this project embraces mesodermal / hematopoietic and germ cell induction from iP-USSC. Besides reprogramming to full pluripotency induction of mesodermal progenitors in USSC will be evaluated.

人脐带血来源的非限制性体干细胞（USSC）可以重编程为诱导多能干细胞（iPS）。本项目通过不同的方法从USSC（iP-USSC）中获得iPS细胞并对其进行表征。将与天然USSC相比评估重编程脐带血细胞的分化潜力。该项目的重点包括来自iP-USSC的中胚层/造血和生殖细胞诱导。此外，将评价重编程至USSC中中胚层祖细胞的完全多能性诱导。