Nanoparticles: Synthesis, characterisation, and cellular effects

纳米颗粒：合成、表征和细胞效应

• 批准号: 57095923
• 负责人: Professor Dr.-Ing. Henning Bockhorn
• 金额: --
• 依托单位: IMK - Atmosphärische Aerosolforschung (IMK- AAF)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/57095923?language=en
• 关键词: Nanoparticles; Synthesis; characterisation; cellular; effects

The aim of the project is to quantify the influence of the properties of metal-oxide nanoparticles (size, degree of agglomeration, chemical composition, surface properties, and coating) on the induction of cellular signalling pathways which are characteristic for the response to oxidative stress and immune reactions. Within the framework of the project proposed, nanoparticles with defined composition, size distribution, and surface properties will be synthesised, transferred into an aerosol with defined size/morphology, and deposited on lung cells via the air/liquid interface with well defined mass, number, and surface doses. Ultimately, the biological responses in cell systems will be quantified, the nanoparticles will be localised in the cellular compartments and the underlying mechanisms of action will be analysed.

该项目的目的是量化金属氧化物纳米颗粒的性质（尺寸，团聚程度，化学成分，表面性质和涂层）对诱导细胞信号传导途径的影响，这些信号传导途径是对氧化应激和免疫反应的响应的特征。在所提出的项目框架内，将合成具有确定的组成、尺寸分布和表面性质的纳米颗粒，将其转移到具有确定的尺寸/形态的气溶胶中，并通过空气/液体界面以明确的质量、数量和表面剂量沉积在肺细胞上。最终，细胞系统中的生物反应将被量化，纳米颗粒将被定位在细胞区室中，并将分析潜在的作用机制。