Synthesis and Characterisation of Tracer-Functionalised Nanoparticles

点击翻译按钮获取中文摘要

This project aims to engineer nanomaterials by utilising gold nanochemistry and neural tracing capabilities of plant-based, nontoxic proteins. In a significant departure from current nanomaterials being developed, functionalising nanoparticles with the tracers enable them to undergo path-specific axonal retrograde transport, transneuronal transport, and anatomical tract flow to bypass the blood-brain barrier. Microfluidics will be used to characterise the neuronal activities of the synthesised nanoconjugates of different sizes and compositions to understand their bio-interactions with axons, synapses, and neuromuscular junctions. The results will lead to a new class of functional nanomaterials as well as cell-based functional assays.