Synthesis and Characterisation of Tracer-Functionalised Nanoparticles

示踪剂功能化纳米粒子的合成和表征

• 批准号: DP230102641
• 负责人: Prof Guangzhao Mao
• 金额: $ 35.93万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102641
• 关键词: Synthesis; Characterisation; Tracer; Functionalised; Nanoparticles

This project aims to engineer nanomaterials by utilising gold nanochemistry and neural tracing capabilities of plant-based, nontoxic proteins. In a significant departure from current nanomaterials being developed, functionalising nanoparticles with the tracers enable them to undergo path-specific axonal retrograde transport, transneuronal transport, and anatomical tract flow to bypass the blood-brain barrier. Microfluidics will be used to characterise the neuronal activities of the synthesised nanoconjugates of different sizes and compositions to understand their bio-interactions with axons, synapses, and neuromuscular junctions. The results will lead to a new class of functional nanomaterials as well as cell-based functional assays.

该项目旨在通过利用黄金纳米化学和植物无毒蛋白质的神经追踪能力来设计纳米材料。与目前正在开发的纳米材料相比，具有示踪剂的功能化纳米颗粒使它们能够经历路径特异性轴突逆行运输，跨神经元运输和解剖管道流动以绕过血脑屏障。微流体技术将被用于分析不同大小和组成的合成纳米缀合物的神经元活动，以了解它们与轴突、突触和神经肌肉接头的生物相互作用。结果将导致一类新的功能纳米材料以及基于细胞的功能测定。