Elucidating the mechanisms underlying state dependent sensory processing

阐明状态依赖的感觉处理的机制

• 批准号: 22K06490
• 负责人: Lindeman Sander
• 金额: $ 2.58万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06490/
• 关键词: Neurosicence; State-dependent; Inhibition; Sensory Processing; olfaction; inhibition; neuroscience

In FY 2022 we have successfully ran experiments to identify subcellular specificity of sate-dependent inhibition. We have recorded neural activity from different compartments of two types of output neurons in the olfactory bulb. With these data we were able to identify where in these cells (in which compartments) inhibition occurred in a behavioural relevant context. We thus have successfully reach our milestone for this fiscal year. In addition, we started to run experiments to identify the source of this inhibition. The preliminary results were shared at a major international neuroscience conference in November and have been positively received by our peers.

于2022财政年度，我们已成功进行实验以识别盐依赖性抑制的亚细胞特异性。我们记录了嗅球中两种类型输出神经元的不同隔室的神经活动。有了这些数据，我们能够确定在这些细胞（在哪些隔室）中，在行为相关的背景下发生抑制。因此，我们已成功达到本财政年度的里程碑。此外，我们开始进行实验，以确定这种抑制的来源。初步结果在11月的一次重要国际神经科学会议上分享，并得到了同行的积极评价。