Brain iron deposition in neurodegenerative disorders examined by MRI T2 relaxometry, pathology and biochemistry: comparative study

通过 MRI T2 弛豫测量、病理学和生物化学检查神经退行性疾病中的脑铁沉积：比较研究

• 批准号: 58038013
• 负责人: Dr. Katherine Schweitzer
• 金额: --
• 依托单位: Department of Neurology
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/58038013?language=en
• 关键词: Brain; iron; deposition; neurodegenerative; disorders

Signal alterations could be shown in T2 relaxometry on MRI (MRR) in Parkinson’s disease (PD) patients in the anatomical area of the substantia nigra (SN). The findings seem to correspond to alterations in tissue echogenicity of the respective regions on transcranial ultrasound (TCS). Although changes in tissue iron content have been discussed as one reason for the neuroimaging alterations, it is not clear to what extent this heavy metal contributes to the changes or whether other factors may play a role. The aim of the proposed project is to investigate the SN iron content in different neurodegenerative disorders (e.g. idiopathic PD and atypical parkinsonian diseases (APD)) by MRR, TCS and corresponding histopathological examinations in comparison to healthy controls. The study of tissues will show the amount of iron, the type of iron storage and the kind of protein iron binding (Fe II, Fe III and iron bound to Neuromelanin) and correlate these findings with the appearance in the different imaging techniques. This will help us to understand the specific pathophysiology of the respective disorders and show the possibilities of MRR as well as TCS in detecting the respective role of iron, which may lead to earlier diagnosis and subsequent neuroprotective treatment strategies.

帕金森病(PD)患者的MRI(MRR)T2弛豫法可显示黑质(SN)解剖区域的信号改变。这些发现似乎与经颅超声(TCS)上相应区域组织回声的变化相一致。尽管组织铁含量的变化被讨论为神经成像变化的原因之一，但尚不清楚这种重金属在多大程度上导致了这种变化，也不清楚其他因素是否可能起作用。本项目的目的是通过MRR、TCS和相应的组织病理学检查来研究不同神经退行性疾病(如特发性帕金森病和不典型帕金森病)中SN铁的含量，并与健康对照组进行比较。对组织的研究将显示铁的数量、铁储存的类型和蛋白铁结合的种类(铁II、铁III和与神经黑素结合的铁)，并将这些发现与不同成像技术中的外观相关联。这将有助于我们了解各自疾病的特定病理生理机制，并显示MRR和TCS在检测铁的各自作用方面的可能性，这可能导致早期诊断和后续的神经保护治疗策略。