Glutathione modulates the extracellular matrix organization of craniofacial neural crest cells in Type 3 POLR1C Treacher Collins syndrome

点击翻译按钮获取中文摘要

The project applied the polr1c zebrafish mutant to study the Tracher Collins syndrome (TCS). Excessive reactive oxidative species were found in the mutant, and we have screened several anti-oxidants for potential treatment. In the past year, we have customized the facial micro-CT analysis in zebrafish for bone mineral density measurement (Liao et al. 2022). Besides, we analyzed the genotype-phenotype correlations in TCS (Ulhaq et al. 2022) and Nager syndrome (Ulhaq et al. In Press). Furthermore, we applied the developed methodologies to study the motor deficits in zebrafish (Ulhaq et al. 2023). Lastly, a review paper on deubiquitinates has been published (Liu et al. 2022).