Secondary neuroinflammation in the CNS white matter and its modulation by erythropoietin (B06)

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The project will investigate the functional integrity of CNS white matter tracts in mouse models of MS when the myelin sheath becomes an inflammatory target of autoaggressive T cells and activated microglia/macrophages. The novelty of this work stems from the recent discovery that oligodendrocytes provide metabolic support to myelinated axons and that the integrity of 'myelinic channels' is required to maintain rapid metabolic fluxes from oligodendrocytes to the axonal compartment.