CNS-Met Administrative Core

项目摘要-行政核心 中枢神经系统代谢的研究已经引起了许多领域的兴趣，包括阿尔茨海默病，脑代谢， 损伤（包括创伤性损伤，中风等），癫痫和帕金森病，并可能涉及所有领域， CNS相关研究肯塔基州大学医学院在以下方面进行了大量投资： 在过去的几年里，代谢组学仪器和具有代谢组学专业知识的研究人员， 增强了英国在神经科学、癌症、心血管、糖尿病和肥胖症研究方面的现有优势。的 本申请的目的是在CNS中创建NIH生物医学研究卓越中心（COBRE 代谢（CNS-Met）。这项建议建立在英国现有的优势，以及双方的高级优势， 以及脑生理学、神经病理学和中枢神经系统代谢的初级研究者。CNS-Met 管理核心（Admin Core）将协调CNS-Met组之间的通信和访问， 上述以代谢为中心的研究计划，以及其他现有的英国优势，以及核心 由其他英国COBREs建立的设施，以支持多学科，以团队为基础的计划，培训 下一代的教师专注于大脑代谢。CNS-Met行政核心由博士指导。 Matthew Gentry和帕特里克沙利文博士共同指导，资深科学家在CNS领域具有互补的专业知识 新陈代谢和领导能力。核心将确保和提供有效的协调， 监督研究项目，研究核心的使用和服务，一般基础设施，行政， 财政问题。它将提供有力和及时的财务管理，并将促进内部沟通 CNS-Met成分之间。它将负责协调未来研究项目的招聘 领导者和导师，以及管理和实施试点计划的资金。管理核心将完成所有 这些活动，同时确保CNS-Met活动符合联邦法规。的 CNS-Met行政核心的总体目标是提供行政、财政和科学服务， 领导和中心范围内的协调COBRE研究项目领导人，他们的导师，研究 核心和其他COBRE-supported调查人员。为了实现这些目标，核心将：1）协调 运营和财务管理、基础设施和项目规划以及沟通流程 在所有COBRE组件中。2）促进和协调研究培训，指导和职业生涯 为脑代谢研究的早期研究者开展开发活动; 3）开展试点研究 在神经科学研究方向上开展新研究的计划;以及4）提供有效的形成性和 COBRE项目和CNS-Met小组活动的总结性评估。

PROJECT SUMMARY – ADMINISTRATIVE CORE Research in CNS metabolism has garnered interest from many fields, including Alzheimer’s Disease, brain injury (including traumatic injury, stroke, etc), epilepsy, and Parkinson’s Disease, and likely involves all areas of CNS-related research. The University of Kentucky College of Medicine has made significant investments over the last few years in both metabolomics instrumentation and investigators with metabolomics expertise that enhanced existing UK strengths in neuroscience, cancer, cardiovascular, and diabetes & obesity research. The objective of this application is to create an NIH Center of Biomedical Research Excellence (COBRE) in CNS Metabolism (CNS-Met). This proposal builds on existing strengths at UK as well as strengths of both the senior and junior investigators in brain physiology, neuropathology, and CNS metabolism. The CNS-Met Administrative Core (Admin Core) will coordinate communication and access among the CNS-Met groups, the above-mentioned metabolism-centric research programs, and other existing UK strengths as well as core facilities established by other UK COBREs to support a multidisciplinary, team-based program that trains the next generation of faculty focused on brain metabolism. The CNS-Met Administrative Core is directed by Dr. Matthew Gentry and co-directed by Dr. Patrick Sullivan, senior scientists with complementary expertise in CNS metabolism and demonstrated leadership skills. The Core will ensure and provide effective coordination and oversight of research projects, research cores usage and service, general infrastructure, administrative, and fiscal matters. It will provide robust and timely financial management and will facilitate internal communication between CNS-Met constituents. It will be responsible for coordinating the recruitment of future research project leaders and mentors and for managing and implementing pilot program funding. The Admin Core will do all of these activities while ensuring that CNS-Met activities are in compliance with federal regulations. The overarching goal of the CNS-Met Administrative Core is to deliver administrative, fiscal, and scientific leadership and center-wide coordination to COBRE Research Project Leaders, their mentors, research core, and other COBRE-supported investigators. To achieve these goals, the core will: 1) Coordinate operational and fiscal management, infrastructure and program planning, and communication processes across all COBRE components.; and 2) Facilitate and coordinate research training, mentoring, and career development activities for early-stage investigators in brain metabolism research; 3) Implement a pilot studies program to seed new research across neuroscience research thrusts; and 4) Provide effective formative and summative assessment of COBRE projects and activities of the CNS-Met group.