CNS-Met Administrative Core

项目总结--行政核心 中枢神经系统代谢的研究已经引起了许多领域的兴趣，包括阿尔茨海默病、脑 损伤(包括创伤性损伤、中风等)、癫痫和帕金森氏症，可能涉及以下所有领域 中枢神经系统相关研究。肯塔基大学医学院在以下方面进行了重大投资 在代谢组学仪器和具有代谢组学专业知识的研究人员的过去几年中 增强英国在神经科学、癌症、心血管、糖尿病和肥胖症研究方面的现有优势。这个 该申请的目标是在CNS创建NIH生物医学研究卓越中心(COBRE 代谢(CNS-Met)。这项建议建立在英国现有优势的基础上，以及两位资深员工的优势 以及脑生理学、神经病理学和中枢神经系统新陈代谢方面的初级研究员。CNS-Met 管理核心(管理核心)将协调CNS-Met组之间的通信和访问， 上述以新陈代谢为中心的研究计划，以及英国现有的其他优势和核心 由其他英国科布雷人建立的设施，以支持一个多学科的、基于团队的计划，该计划培训 下一代教员专注于大脑新陈代谢。CNS-Met管理核心由Dr. Matthew Gentry和Patrick Sullivan博士共同指导，他们是在CNS方面具有互补专业知识的资深科学家 新陈代谢和卓越的领导能力。该核心将确保和提供有效的协调和 监督研究项目、研究中心的使用和服务、一般基础设施、行政和 财政问题。它将提供健全和及时的财务管理，并将促进内部沟通 在CNS-Met成分之间。它将负责协调未来研究项目的招募工作 领导和导师，以及管理和实施试点项目资金。管理核心将完成所有 这些活动同时确保CNS-Met的活动符合联邦法规。这个 CNS-Met管理核心的总体目标是提供管理、财务和科学 领导和中心范围内对Cobre研究项目负责人、他们的导师、研究人员的协调 Core和其他由Cobre支持的调查人员。为了实现这些目标，核心将：1)协调 运营和财务管理、基础设施和计划规划以及沟通流程 跨所有Cobre组件；以及2)促进和协调研究培训、指导和职业发展 为脑代谢研究的早期研究人员开展活动；3)实施先导研究 为跨神经科学研究的新研究提供种子的计划；以及4)提供有效的形成性和 对COBRE项目和CNS-Met小组活动的总结性评估。

PROJECT SUMMARY – ADMINISTRATIVE CORE Research in CNS metabolism has garnered interest from many fields, including Alzheimer’s Disease, brain injury (including traumatic injury, stroke, etc), epilepsy, and Parkinson’s Disease, and likely involves all areas of CNS-related research. The University of Kentucky College of Medicine has made significant investments over the last few years in both metabolomics instrumentation and investigators with metabolomics expertise that enhanced existing UK strengths in neuroscience, cancer, cardiovascular, and diabetes & obesity research. The objective of this application is to create an NIH Center of Biomedical Research Excellence (COBRE) in CNS Metabolism (CNS-Met). This proposal builds on existing strengths at UK as well as strengths of both the senior and junior investigators in brain physiology, neuropathology, and CNS metabolism. The CNS-Met Administrative Core (Admin Core) will coordinate communication and access among the CNS-Met groups, the above-mentioned metabolism-centric research programs, and other existing UK strengths as well as core facilities established by other UK COBREs to support a multidisciplinary, team-based program that trains the next generation of faculty focused on brain metabolism. The CNS-Met Administrative Core is directed by Dr. Matthew Gentry and co-directed by Dr. Patrick Sullivan, senior scientists with complementary expertise in CNS metabolism and demonstrated leadership skills. The Core will ensure and provide effective coordination and oversight of research projects, research cores usage and service, general infrastructure, administrative, and fiscal matters. It will provide robust and timely financial management and will facilitate internal communication between CNS-Met constituents. It will be responsible for coordinating the recruitment of future research project leaders and mentors and for managing and implementing pilot program funding. The Admin Core will do all of these activities while ensuring that CNS-Met activities are in compliance with federal regulations. The overarching goal of the CNS-Met Administrative Core is to deliver administrative, fiscal, and scientific leadership and center-wide coordination to COBRE Research Project Leaders, their mentors, research core, and other COBRE-supported investigators. To achieve these goals, the core will: 1) Coordinate operational and fiscal management, infrastructure and program planning, and communication processes across all COBRE components.; and 2) Facilitate and coordinate research training, mentoring, and career development activities for early-stage investigators in brain metabolism research; 3) Implement a pilot studies program to seed new research across neuroscience research thrusts; and 4) Provide effective formative and summative assessment of COBRE projects and activities of the CNS-Met group.