FOR 1086: K2P-Channels - From Molecules to Physiology and Pathophysiology

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Two-pore-domain potassium channels (K2P-channels) represent the most recently discovered class of potassium channels. The family of K2P-channels in humans comprises 15 members. The name of the channels was derived from their structure: Every subunit possesses two pore domains and four transmembrane domains. Functional K2P-channels assemble as dimers, in which altogether four pore domains form a potassium-selective pore (all other potassium channels possess only one pore domain per subunit and assemble as tetramers). The activity of K2P channels is regulated in a very complex manner, for example by neurotransmitters, by local pH changes, polyunsaturated fatty acids, mechanical stretch of the membrane, heat and inhalation anaesthetics. K2P-channels are potentially interesting drug targets and could open up new strategies for the treatment of various diseases. The pathophysiologically interesting processes in which K2P-channels are involved include neuroprotection, inhalation anaesthesia, nociception, epilepsy, cardiac arrhythmias, renal disturbances of salt- and water balance, pulmonary hypertension, cell proliferation and endocrine disorders. The aim of the Research Unit is to unite the research groups working in Germany in the field of K2P-channels to a joint project: the elucidation of the physiology and pathophysiology of K2P-channels and the development of new therapeutic strategies with K2P-channels as drug targets. The Research Unit aims to