Infection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in South and Central Afrika

南非和中非葡萄球菌和葡萄球菌疾病的感染生物学和流行病学

• 批准号: 68523460
• 负责人: Professor Dr. Hagen von Briesen
• 金额: --
• 依托单位: Fraunhofer-Institut für Biomedizinische Technik (IBMT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/68523460?language=en
• 关键词: Infection; Biology; Epidemiology; Staphylococci; Staphylococcal

Staphylococcus aureus continues to be a major pathogen causing invasive disease with high associated morbidity and mortality. The pathogen has acquired resistance against virtually all antimicrobials available, and in the recent years, the worldwide emergence of multiresistant S. aureus clones in hospitals and communities has spurred significant concern for local and global health initiatives. In contrast to the ‘classical’ tropical diseases, however, almost nothing is known on the strain phylogeny and prevalence, disease type, and associated morbidity and mortality of infections due to S. aureus in most African countries. This proposal submitted by four sub-Saharan African and five German groups thus focusses on a registry of S. aureus community-acquired disease, on the isolation and characterization of clinical isolates with advanced methods for typing and virulence factor expression, and on GLP-conform long-term isolate handling and scientific database exchange. Emerging information will allow to associate S. aureus biology with course of disease, and thus provide a basis for future rational multifaceted interventions including diagnostics, therapy, and preventive measures tailored to the resources and requirements of sub- Saharan Africa. Moreover, the applied academic exchange and workshop program as well as case ascertainment and isolate characterization based on shared criteria and techniques will foster the combat against this pathogen in African countries as well as in Germany.

金黄色葡萄球菌仍然是导致侵袭性疾病的主要病原体，具有高相关发病率和死亡率。该病原体对几乎所有可用的抗菌药物都具有耐药性，近年来，世界范围内出现了多重耐药的S。医院和社区中的金黄色葡萄球菌克隆引起了对地方和全球卫生倡议的重大关注。然而，与“经典”热带病相比，几乎对菌株的遗传和流行、疾病类型以及由S引起的感染的相关发病率和死亡率一无所知。在大多数非洲国家。因此，由四个撒哈拉以南非洲国家和五个德国团体提交的这一提案侧重于S。金黄色葡萄球菌社区获得性疾病，临床分离株的分离和鉴定与先进的方法分型和毒力因子表达，以及GLP符合长期分离株处理和科学数据库交换。新出现的信息将使S.金黄色葡萄球菌生物学与病程的关系，从而为未来合理的多方面干预措施提供基础，包括针对撒哈拉以南非洲资源和需求的诊断、治疗和预防措施。此外，应用学术交流和研讨会计划以及基于共享标准和技术的病例确定和分离表征将促进非洲国家和德国对抗这种病原体的斗争。