A study on a new vitamin E

我们已经从鲑鱼卵的亲脂性部分中分离出一种新的α-生育单烯酚，其在普遍存在的α-生育酚（α-Toc）的末端植基链处具有不寻常的亚甲基不饱和。这种海洋衍生的生育酚（MDT）被发现在高比例与α-TOC的浮游植物和浮游动物样本中捕获的冷水环境中的北太平洋（北海道海）和我们的发现，水产养殖鲑鱼喂养的MDT无饮食有很少MDT表明，MDT是营养收购自然浮游植物生产的冷水食物链。我们发现MDT和alpha-Toc在体外的抗氧化活性差异不大，但在0 ℃时观察到MDT在鱼油中的活性更高。同样，我们发现MDT在粘性、胆固醇掺入的脂质体膜中的表现优于alpha-Toc。我们的研究结果表明，MDT可能提供了一个重要的生理优势，在抗氧化功能的冷水海洋生物。

We have isolated a new a-tocomonoenol from the lipophilic fraction of salmon eggs which has an unusual methylene unsatutation at the terminal phytyl chain of ubiquitous alpha-tocopherol (alpha-Toc). This marine-derived tocopherol (MDT) was found at high ratio with alpha-Toc in phytoplankton and zooplankton samples captured in the cold-water environment of the North Pacific Ocean (Hokkaido Sea) and our finding that aquaculutured salmon fed with a MDT-free diet had little MDT suggest that MDT is trophically acquired from natural phytoplankton production in the cold-water food-chain. We found little difference in the antioxidant activity between MDT and alpha-Toc in vitro, but observed higher activity for MDT in fish oil at 0ﾟC.Similarly, we found that MDT performed better than alpha-Toc in viscous, cholesterol-incorporated liposomal membranes than in cholestrol-free liposome. Our results suggest that MDT may provide an important physiological advantage in antioxidant functions of cold-water marine organisms.