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The link between skeletal and smooth muscle : Evolution of E-C coupling factor

骨骼肌和平滑肌之间的联系：E-C耦合因子的演变

基本信息

批准号：
09680663
负责人：
TSUTSUI Izuo
金额：
$ 2.18万
依托单位：
Okazaki National Research Institutes
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680663/
关键词：
Doliolum sarcoplasmic reticulum T system E-C coupling Ciona caffeine Branchiostoma Sagitta Diphys E-C coupling 膜内電荷移動ユウレイボヤ DICR ウミタルナメクジウオ

项目摘要

In this study, I have investigated the link factor which converts the smooth muscle to the skeletal muscle using marine animals.Marine animals have a large varieties of combinations of organelles, which control the contraction of the muscle cells, i. e., sarcoplasmic reticulum (SR), transvers tubular structure (T system), Ca channel, ryanodine receptor and DHP receptor.Heart muscles of Ascidia Ciona, which has SR but not T system, requires extracellular Ca for its contraction and usually behaves like smooth muscle.But by adding caffeine or replacing external Cl to SCN, heart muscle contracted by electrical stimulations in the absence of external Ca like skeletal muscle.On the other hand, on pelagic tunicate Doliolum, which lacks T and SR organelles, muscle contracted only in the presence of external Ca, even if caffeine was present.It is suggested that the presence of SR is essential for skeletal muscle type contraction and the E-C coupling factor exist on SR even if it is not active.The coupling factor suggested to be existed in smooth muscle SR but the coupling might be very loose.By developing the coupling, smooth muscle maight be converted to skeletal muscle.

在本研究中，我用海洋动物研究了将平滑肌转化为骨骼肌的连接因子。海洋动物具有多种细胞器组合，它们控制着肌肉细胞的收缩，例如，肌浆网（SR），横管状结构（T系统）、Ca通道、ryanodine受体和DHP受体。海鞘（Ascidia Ciona）的心肌具有SR而不具有T系统，其收缩需要细胞外Ca，并且通常表现为平滑肌。但是，通过添加咖啡因或将外部Cl替换到SCN中，在缺乏外部Ca的情况下，心肌在电刺激下收缩类似于骨骼肌。另一方面，在缺乏T和SR细胞器的远洋被囊类海豚（DoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliocaticsDoliaticsDoliocaticsDolioc平滑肌可以转化为骨骼肌。