Stress-induced programming in serotonin (5-HT) system-modified mice: epigenetic editing as a strategy to cope with anxiety (A05)

血清素 (5-HT) 系统修饰小鼠的压力诱导编程：表观遗传编辑作为应对焦虑的策略 (A05)

• 批准号: 78046362
• 金额: --
• 依托单位: Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/78046362?language=en
• 关键词: Stress; induced; programming; serotonin; HT

The aim of the project is the investigation of the role of gene-by-environment interaction in the developmental programming of anxiety disorders the following research objectives: 1) Validation of epigenetically regulated risk and protective genes identified in serotonin transporter (5-Htt) x prenatal stress (PS) paradigm, 2) Investigation of in 1) validated candidate genes in a novel tryptophane hydroxylase (Tph2)-deficient mouse model of panic disorder. 3) Causality assessment and intervention using an in vivo gene- and site-specific epigenetic editing strategy, using e.g. myelin basic protein (Mbp), as a novel strategy to cope with anxiety.

该项目的目的是调查基因与环境的相互作用在焦虑症的发展规划中的作用，研究目标如下：1）在5-羟色胺转运体（5-Htt）X产前应激（PS）范例中鉴定的表观遗传学调节的风险和保护基因的验证，2）在1）中验证的惊恐障碍的新型色氨酸羟化酶（Tph 2）缺陷小鼠模型中的候选基因的研究。3)使用体内基因和位点特异性表观遗传编辑策略进行因果关系评估和干预，例如使用髓鞘碱性蛋白（Mbp）作为科普焦虑的新策略。