Stress-induced programming in serotonin (5-HT) system-modified mice: epigenetic editing as a strategy to cope with anxiety (A05)

点击翻译按钮获取中文摘要

The aim of the project is the investigation of the role of gene-by-environment interaction in the developmental programming of anxiety disorders the following research objectives: 1) Validation of epigenetically regulated risk and protective genes identified in serotonin transporter (5-Htt) x prenatal stress (PS) paradigm, 2) Investigation of in 1) validated candidate genes in a novel tryptophane hydroxylase (Tph2)-deficient mouse model of panic disorder. 3) Causality assessment and intervention using an in vivo gene- and site-specific epigenetic editing strategy, using e.g. myelin basic protein (Mbp), as a novel strategy to cope with anxiety.