Purinergic signalling in placentation and vascular adaptation in pregnancy

妊娠期胎盘形成和血管适应中的嘌呤能信号传导

• 批准号: FT210100193
• 负责人: Prof Natalie Hannan
• 金额: $ 75.82万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT210100193
• 关键词: Purinergic; signalling; placentation; vascular; adaptation

Our traditional understanding of purinergic signalling in the placenta is significantly outdated and incomplete. The placenta is critical for reproduction in all eutherian mammals, delivering critical nutrition and oxygen to the developing fetus. This project aims to define the role of purinergic signalling as a critical mechanism driving placentation and angiogenesis. This is the first study of its kind and will use sophisticated models to improve our fundamental understanding and ability to manipulate mammalian reproduction via the purinoreceptors. This proposal builds on my skills and expertise; improving our knowledge of the processes driving placental and vascular morphogenesis and offers important discoveries for reproductive science.

我们对胎盘中嘌呤能信号的传统理解明显过时和不完整。胎盘对所有真兽目哺乳动物的繁殖至关重要，为发育中的胎儿提供关键的营养和氧气。该项目旨在确定嘌呤能信号作为驱动胎盘形成和血管生成的关键机制的作用。这是同类研究中的第一项，将使用复杂的模型来提高我们对通过嘌呤受体操纵哺乳动物生殖的基本理解和能力。这项提案建立在我的技能和专业知识的基础上;提高我们对胎盘和血管形态发生过程的认识，并为生殖科学提供重要发现。