Regulating the composition of biomolecular condensates in living cells

生物分子凝聚是活细胞的一种新的组织原理，由细胞内容物的“分离”驱动。从植物到动物都可以观察到它，它参与了从细胞如何修复DNA到细胞如何感知信号的各种过程。该项目旨在揭示人类细胞如何控制冷凝物的组成，这对它们的功能至关重要。它希望通过结合定量细胞生物学和统计物理学的方法来揭示细胞组织的新调控原理。预期的好处包括建设澳大利亚在生物分子凝析油这一具有潜在变革性的领域的能力，这一领域未来在卫生和农业方面具有多种生物技术应用。

Biomolecular condensation is a novel organising principle of living cells, driven by ‘unmixing’ of the cellular contents into compartments. It is observed from plants to animals and is involved in diverse processes from how cells repair DNA to how they perceive signals. This project aims to reveal how human cells control the composition of condensates, which is critical for their function. It expects to uncover new regulatory principles of cellular organisation by combining methods from quantitative cell biology and statistical physics. Expected benefits include building Australia’s capability in the potentially transformational field of biomolecular condensates, which has diverse future biotechnology applications in health and agriculture.