Coordinating gene expression and cell size: the role of feedback regulation

协调基因表达和细胞大小：反馈调节的作用

• 批准号: DE230100271
• 负责人: Dr Scott Berry
• 金额: $ 32.68万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100271
• 关键词: Coordinating; gene; expression; cell; size

This project aims to reveal how human cells coordinate the kinetics of messenger RNA (mRNA) transcript production, processing and degradation at the single-cell level. It expects to generate significant new biological knowledge of gene regulation by combining innovative interdisciplinary research methodologies in genetics, single-molecule imaging, mathematical modelling and quantitative cell biology. Expected outcomes include enhanced training of researchers and to build Australia’s capability in the rapidly expanding fields of RNA biology and high-throughput microscopy. This should provide significant benefits for a myriad of applications including health, agriculture and veterinary sciences.

该项目旨在揭示人类细胞如何在单细胞水平上协调信使RNA（mRNA）转录物的产生，加工和降解的动力学。它期望通过结合遗传学，单分子成像，数学建模和定量细胞生物学的创新跨学科研究方法，产生重要的基因调控新生物学知识。预期成果包括加强对研究人员的培训，并建立澳大利亚在RNA生物学和高通量显微镜等迅速扩大的领域的能力。这将为包括卫生、农业和兽医科学在内的无数应用提供显著的益处。