Studies on benzo [c] phenanthridine alkaloid using novel palladium reagents

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1) Development of general synthetic method for benzo[c]phenanthridine alkaloid using novel palladium reagentsA novel palladium reagent prepared from equimolar Pd(OAc)_2, DPPP, and Bu3P was useful for the internal biaryl coupling reaction of not only triflate-amide but also halo-amide as leaving group. By using this novel Pd reagent, benzo[c]phenanthridine alkaloids, chelerythrine and nitidine were synthesized in good yields.2) Synthetic studies on benzo[d]naphthopyranonesBenzo[d]naphthopyranones, arnottin I, was synthesized by using typical Heck* s reaction conditions.3) Synthetic studies on phenanthridine alkaloidsPhenanthridine alkaloid, trisphaeridine, was synthesized via biaryl coupling reaction using palladium reagent.4) Mechanistic aspect of novel Palladium reagent [Pd(OAc)_2-PPP-Bu_3P]It was found out that molar ratio of Pd phosphine = 1 : 3 is essentially necessary for biaryl coupling reaction