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Pulmonary administration of vasodilators during partial liquid ventilation in ARDS.

ARDS 部分液体通气期间肺部给予血管扩张剂。

基本信息

批准号：
09671541
负责人：
KOICHI Nakazawa
金额：
$ 1.79万
依托单位：
Tokyo Medical & Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671541/
关键词：
ARDS Perflubron Liquid ventilation Partial liquid ventilation perflubyon partial liquid ventilation 急性呼吸不全オレイン酸肺傷害 Perfluorocarbon Vasodilator プロスタグランディンE1 プロスタサイクリン Perfluoro Carbon Liquid ventilation Prostaglandin E_1 Pros

项目摘要

Partial liquid ventilation (PLV) is a new mechanical ventilation strategy for the treatment of ARDS.Gas exchange can be performed through intratracheally administered perfluorocarbon using conventional gas ventilation. The aim of our research was to investigate how to improve gas exchange during PLV.In the first study, we found that incease in gas tidal volume, administration dose of perflubron and PEEP was effective for improving gas exchange during PLV and gas tidal volume was most important for improving PaO2 We also investigated the effects of pulmonary administration of vasodilators during liquid ventilation on gas exchange and pulmonary circulation in oleic acid lung injury using rabbit. The administration of aerosolized prostacyclin and nitric oxide in combination with PLV improved PaO2 better than each treatment alone. The mean pulmonary artery pressure significantly decreased with aerosolized prostacyclin or nitric oxide in combination with PLV.Systemic blood pressure was not decreased with those treatments. Intratracheal vasodilators combined with PLV not only improves PaO2, but also reduces the PAP and PVR, leading to systemic circulatory improvement in rabbits with acute respiratory distress syndrome. These findings suggest that intratracheal vasodilators during PLV may offer a simple, alternative treatment for acute respiratory distress syndrome with pulmonary hypertension.

部分液体通气（PLV）是治疗ARDS的一种新的机械通气策略。气体交换可以通过气管内给予全氟化碳使用常规气体通气来进行。我们研究的目的是探讨如何改善PLV期间的气体交换。在第一项研究中，我们发现增加气体潮气量、perflubron和PEEP的给药剂量对于改善PLV期间的气体交换是有效的，并且气体潮气量对于改善PaO2最重要。我们还使用兔子研究了液体通气期间给予血管扩张剂对气体交换和肺循环的影响。雾化前列环素和一氧化氮联合 PLV 改善 PaO2 的效果优于单独治疗。雾化前列环素或一氧化氮与 PLV 联合治疗后，平均肺动脉压显着降低。这些治疗并未降低全身血压。气管内血管扩张剂联合PLV不仅可以改善PaO2，还可以降低PAP和PVR，从而改善急性呼吸窘迫综合征家兔的全身循环。这些发现表明，PLV 期间气管内血管扩张剂可能为伴有肺动脉高压的急性呼吸窘迫综合征提供一种简单的替代治疗方法。