Correlation of clinical data and polymorphism for αィイD21aィエD2-adrenoceptor subtypes gene in Japanese patients with benign prostatic hypertrophy

One ofαI D 21 a I D 2-adrenoceptor subtypes，αI D 21 a I D 2-adrenoceptor is implicated in the pathophysiology of benign prostatic hypertrophy(BPH)。We examined polymorphism of the human ala-AR gene(Arg492to Cys)in 222BPH patients。There was no significant association ofαI D21a文件D2-adrenoceptor polymorphism with clinical(onset and degree of symptoms，size of BPH and response toα锡D21a文件D2-adrenoceptor blocker)and laboratory data(cholesterol and other lipid data，prostatic specific antigen，testosterone level)of the patient with BPH；however，the allele frequency in Japan was markedly different from US populs.The results did support the idea that BPH is associated with alterations inαI D21a THE D2-adrenoceptor gene.

One of αィイD21aィエD2-adrenoceptor subtypes ,αィイD21aィエD2-adrenoceptor is implicated in the pathophysiology of benign prostatic hypertrophy (BPH). We examined polymorphism of the human ala-AR gene (Arg492 to Cys) in 222 BPH patients. There was no significant association of αィイD21aィエD2-adrenoceptor polymorphism with clinical (onset and degree of symptoms, size of BPH and response to αィイD21aィエD2-adrenoceptor blocker) and laboratory data (cholesterol and other lipid data, prostatic specific antigen, testosterone level) of the patient with BPH ; however, the allele frequency in Japan was markedly different from US populations. The results did support the idea that BPH is associated with alterations in αィイD21aィエD2-adrenoceptor gene.