PATHOGENESIS OF ACQUIRED RENAL CYSTIC DISEASE OF THE KIDNEYS WITH TUMOR GENESIS -EXPERIMENTAL STUDY-

血液透析可改善慢性肾功能衰竭患者的预后。但获得性肾囊性疾病（ACDK）发生在长期生存病例的原肾，其发生率较高的肾细胞癌（RCC）。每当认为ACDK的粘膜是通过腺瘤获得生长能力而发展为腺癌时，其机制尚不清楚。在我们的研究中，我们尝试制作大鼠acdk模型，并研究生长因子在其机制中的作用。50只SD大鼠（6周）分为4组。A组：对照组。B组：强制口服OXCa各50g制造ACDK， C组：强制饮水链脲佐菌素（SZ）各0.6g制造RCC， D组：口服OXCa各50g， SZ 0.6g。90 D后，我们将大鼠放生，用HE染色、免疫组化染色（细胞角蛋白和双蛋白）和TUNEL染色进行组织比较。结果B组和d组均可见肾囊肿，但囊肿未见肾细胞癌。

Haemodialysis improved the prognosis of CRF patients. But acquired cystic disease of kidney (ACDK) occurred in original kidneys in long survival cases, which have higher rates of the incidence of renal cell carcinoma(RCC). Whenever it is thought that mucous membranes of ACDK acquired the ability of growth and become to adenocarcinoma through adenoma, its mechanism is still in the dark. In our study we tried to make Rat-ACDK models and researched the roles of the growth factors on its mechanism. 50 SD rats (6 week) were divided into 4 groups. Group A : Control. Group B : forced to intake OXCa 50g cach orally to make ACDK, Group C : forced to drink streptozotocin(SZ) 0.6g each in water to make RCC, Group D : OXCa 50g and SZ 0.6g were fed. 90 days later we gamed the rats and compared with them using HE stained, immunohistochemical stained (cytokeratin and bimentin) and TUNEL stained tissues. As a result we could made renal cysts on Group B and D.But the cysts didn't have RCC.