PATHOGENESIS OF ACQUIRED RENAL CYSTIC DISEASE OF THE KIDNEYS WITH TUMOR GENESIS -EXPERIMENTAL STUDY-

血液透析改善了CRF患者的预后。但获得性肾囊性疾病(ACDK)多见于存活时间长的原肾，肾细胞癌(RCC)发生率较高。以往认为ACDK的粘膜是通过腺瘤获得生长能力并转化为腺癌的，其机制至今仍不清楚。本研究试图建立大鼠ACDK模型，研究生长因子在其发病机制中的作用。取6周龄SD大鼠50只，随机分为4组。A组：对照组。C组：口服链脲佐菌素(SZ)0.6g，制成肾癌；D组：口服OXCa50g和SZ 0.6g，制成肾癌。90d后处死大鼠，用HE染色、免疫组织化学染色(细胞角蛋白和bimentin)和TUNEL染色组织学方法进行比较。结果B组和D组均可形成肾囊肿，但未见肾细胞癌。

Haemodialysis improved the prognosis of CRF patients. But acquired cystic disease of kidney (ACDK) occurred in original kidneys in long survival cases, which have higher rates of the incidence of renal cell carcinoma(RCC). Whenever it is thought that mucous membranes of ACDK acquired the ability of growth and become to adenocarcinoma through adenoma, its mechanism is still in the dark. In our study we tried to make Rat-ACDK models and researched the roles of the growth factors on its mechanism. 50 SD rats (6 week) were divided into 4 groups. Group A : Control. Group B : forced to intake OXCa 50g cach orally to make ACDK, Group C : forced to drink streptozotocin(SZ) 0.6g each in water to make RCC, Group D : OXCa 50g and SZ 0.6g were fed. 90 days later we gamed the rats and compared with them using HE stained, immunohistochemical stained (cytokeratin and bimentin) and TUNEL stained tissues. As a result we could made renal cysts on Group B and D.But the cysts didn't have RCC.