Phytopreventive and Phytotherapeutic Application to Dentistry - Anti-dental caries and anti-periodontal disease activity, and oral retentivity after application of edible phytochemical flavonoids and alkaloids -

为将植物预防和植物治疗策略应用于口腔医学，本研究对食用植物中的黄酮类和甾体类成分进行了抗龋齿和牙周病活性、口腔滞留性及药理机制的研究.黄酮类化合物：（1）多种植物的筛选提供了一种对龋齿和MRSA感染具有有效效用的抗菌黄酮。(2)建立了同时测定唾液中8种儿茶素的高效液相色谱法。(3)该方法可用于多羟基黄酮类化合物的定量研究。(4)口腔药代动力学研究表明，抗龋儿茶素在漱口后在口腔中保留，这种保留是由于它们在口腔不同部位的吸附。(5)以洗必泰为对照品，评价儿茶素的防龋作用。(6)膜流动性降低的影响被发现使用 ...更多信息 研究黄酮类化合物的防龋和抗菌作用。(7)在食用植物的筛选中，发现洋葱中含有类黄酮胶原酶抑制剂，进而研究开发抗牙周病的植物药.生物碱：（1）β-咔啉类抑制引起龋齿和牙周病的口腔细菌的生长。（二）、建立了HPLC法测定食药用植物中具有生物活性的β-咔啉类化合物的方法。(3)在功能性食品筛选中，对酱料中的两种β-咔啉类化合物进行了抗血小板聚集作用的研究，并对其抗血小板作用机制进行了初步探讨。(4)一系列的植物化学研究表明，与酒精中毒有关的β-咔啉与全身/局部麻醉药之间存在相互作用，膳食β-咔啉代谢缺乏可能是导致某种精神障碍的原因。β-咔啉生物碱已被研究为慢性酒精摄入和婴儿自闭症麻醉耐受的可能病因因素。少

To apply the phytopreventive and phytotherapeutic strategies to dentistry, the flavonoidal and alkaloidal components in edible plants were studied concerning the anti-dental caries and anti-periodontal disease activity, the retentive property in oral cavity, and the pharmacological mechanism.1. Flavonoids : (1) Screenings of various plants provided an antibacterial flavone with the potent utility for dental caries and MRSA infection. (2) An HPLC method was developed for the simultaneous determination of eight catechins in saliva. (3) The method was applied to quantitative studies of pharmacologically active polyhydroxyflavonoids. (4) Oral pharmacokinetic studies revealed that anti-caries catechins were retained in oral cavity after mouthrinsing, and such retentivity was due to their adsorption to different oral sites. (5) The caries-preventive utility of catechins was evaluated comparatively with chlorhexidine as a reference agent. (6) Membrane fluidity-reducing effects were found to u … More nderlie the anti-caries and anti-bacterial actions of flavonoids. (7) In screening of edible plants, onion was found to contain a flavonoidal collagenase-inhibitor , followed by studies to develop the phytomedicine against periodontal diseases.2. Alkaloids : (1) Beta-carbolines inhibited the growth of oral bacteria responsible for dental caries and periodontal diseases. (2). An HPLC method was developed for the determination of pharmacologically active β-carbolines in edible and medicinal plants. (3) In screenings of functional foodstuffs, two β-carbolines in soy sauce inhibited human platelet aggregation, followed by educidation of their anti-platelet mechanism. (4) A series of phytochemical studies suggested the interaction between alcoholism-relating β-carboline and general/local anesthetics, and the responsibility of metabolic deficiency of dietary β-carboline for the pathogenesis of a certain mental disorder. Beta-carboline alkaloids have been studied as a possible etiological factor of anesthetic tolerance by chronic alcohol intake and infantile autism. Less