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Corticosteroid irrigation of parotid gland for treatment of xerostomia in patients with Sjogren's syndrome

腮腺皮质类固醇冲洗治疗干燥综合征患者口干症

基本信息

批准号：
09671927
负责人：
IZUMI Masahiro
金额：
$ 2.05万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671927/
关键词：
Sjogren's syndrome MRI fat deposition xerostomia corticosteroids treatment シェ-グレン症候群

项目摘要

The purpose of this study was to determine the efficacy of corticosteroid irrigation of the parotid gland in relieving salivary flow deficiency in patients with Sjogren's syndrome.The parotid glands of thirty-nine patients with primary (twenty nine) or secondary (ten) Sjogren's syndrome were irrigated either with saline solution followed by corticosteroid solution. Salivary function was assessed by Saxon test.Corticosteroid irrigation significantly increased the salivary flow rate in patients with Sjogren's syndrome (p< 0.0001), with clinical improvement detectable 4.0 "*" 2.6 weeks after initial corticosteroid irrigation. The extent of improvement in salivary function was reciprocal to the clinical severity of the disease, with patients at the early stages obtaining 1.20*0.57 g net increase in salivary flow rate, and patients at the most advanced stages obtaining 0.20 "*" 0.47 g net increase. Repeated steroid irrigations did not evoke steroid refractoriness of the salivary gland ; similar levels of net increase in salivary flow rate were observed after the second to fourth challenge of the corticosteroid in these patients. The sustained period was 8.6 months.These findings suggest the clinical usefulness of corticosteroid irrigation therapy in relieving xerostomia in patients with Sjogren's syndrome.

本研究的目的是确定皮质类固醇冲洗腮腺在缓解干燥综合征患者唾液流量不足方面的功效。对 39 名原发性（29 名）或继发性（10 名）干燥综合征患者的腮腺先用盐水溶液冲洗，然后用皮质类固醇溶液冲洗。通过 Saxon 试验评估唾液功能。皮质类固醇冲洗显着增加了干燥综合征患者的唾液流量 (p< 0.0001)，初次皮质类固醇冲洗后 2.6 周可检测到临床改善 4.0“*”。唾液功能改善的程度与疾病的临床严重程度成反比，早期患者获得唾液流量净增加1.20*0.57g，最晚期患者获得0.20“*”0.47g净增加。重复类固醇冲洗不会引起唾液腺类固醇无效；在这些患者中第二次至第四次皮质类固醇挑战后，观察到相似水平的唾液流量净增加。持续时间为8.6个月。这些结果表明皮质类固醇冲洗疗法在缓解干燥综合征患者口干症方面的临床有效性。