Sjogren's Syndrome in patients with HTLV-I-associated myelopathy(HAM) :

HTLV-I 相关脊髓病 (HAM) 患者的干燥综合征：

• 批准号: 11671872
• 负责人: IZUMI Masahiro
• 金额: $ 2.18万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671872/
• 关键词: HAM; Salivary gland; dry mouth; HTLV-1; MRI; Sjogren's syndrome; MR1; HTLV-1

Objective.To characterize imaging features of the major salivary glands in patients with HTLV-I-associated myelopathy(HAM) who were associated with Sjogren's syndrome, and to compare these features with those in HAM-negative patients with Sjogren's syndrome. Subjects and Methods. The study propulation included 31 HAM patients(12 were associated with Sjogren's syndrome), 15 HTLV-I-seropositive/HAM-negative patients with Sjogren's syndrome, and 41 HTLV-I-seronegative patients with Sjogren's syndrome. Separate 20 HAM-negative patients with sicca syndrome only were also studied. Diagnostic imaging(sialography, MR imaging, and sonography) of the salivary glands. labial gland biopsy, Schirmer test, Saxon test and serological tests were performed on these patients. Results. The parotid and submandibular glands in 11(92%) of the 12 HAM patients with Sjogren's syndrome completely lacked the abnormal imaging features characteristic of the disease, while they displayed decreased salivary flow rates at levels similar to those in the HAM-negative patients with Sjogren's Syndrome. The labial glands from the HAM patients with Sjogren's syndrome exhibited significantly lower magnitudes of mononuclear cell aggregation compared with those in the HAM-negative patients with Sjogren's syndrome. In contrast, all HAM-negative patients with Sjogren's syndrome showed abnormal imaging features characteristic of the disease, and the severity in salivary dysfunction correlated well with the imaging findings.Conclusion. These results suggest that Sjogren's syndrome in HAM patients may at least in part occur via a distinctive mechanism from classical Sjogren's syndrome in HAM-negative patients.

目的：描述与干燥综合征相关的HTLV-Ⅰ相关脊髓病（HAM）患者的大唾液腺影像学特征，并与HAM阴性的干燥综合征患者进行比较。主题和方法。该研究包括31例HAM患者（12例与Sjogren综合征相关），15例HTLV-I血清阳性/HAM阴性的Sjogren综合征患者，41例HTLV-I血清阴性的Sjogren综合征患者。另外还研究了20例仅患有干燥综合征的HAM阴性患者。唾液腺的诊断性成像（涎腺造影、MR成像和超声检查）。对患者进行唇腺活检、Schirmer试验、Saxon试验和血清学检查。结果12例HAM患者中有11例（92%）的腮腺和下颌下腺完全缺乏该疾病的异常影像学特征，而唾液流速降低的水平与HAM阴性的Sjogren综合征患者相似。与HAM阴性的干燥综合征患者相比，HAM干燥综合征患者的唇腺表现出显著较低的单核细胞聚集程度。与此相反，所有HAM阴性的干燥综合征患者均表现出该疾病特有的异常影像学特征，且唾液分泌功能障碍的严重程度与影像学表现密切相关。这些结果表明，舍格伦综合征在HAM患者可能至少部分发生通过一个独特的机制，从经典舍格伦综合征在HAM阴性患者。

项目成果

Izumi M 他4名: "Sjogren's syndrome(SS) in patients with Human T Cell Leukemia Virus I associated myelopahy :"J Rheumatol. 26. 2609-2614 (1999)

Izumi M 和其他 4 人：“人类 T 细胞白血病病毒 I 相关脊髓病患者中的干燥综合征 (SS)：”J Rheumatol。26. 2609-2614 (1999)

Chikui T, 他4名: "Abnormal blood inflows to the submandibular glands of patients with Sjogren's syndrome : Doppler waveform analysis"J Rheumatol. 27. 1222-1228 (2000)

Chikui T 等 4 人：“干燥综合征患者下颌下腺的异常血液流入：多普勒波形分析”J Rheumatol. 27. 1222-1228 (2000)。

T, Chikui et al: "Abnormal blood inflows to the submandibular glands of patients with Sjogren's syndrome : Doppler waveform analysis"J Rheumatol. 27. 1222-1228 (2000)

T, Chikui 等人：“干燥综合征患者下颌下腺的异常血液流入：多普勒波形分析”J Rheumatol。

M, Izumi et al: "Sjogren's syndrome(SS) in patients with Human T Cell Leukemia Virus I associated myelopahy :"J Rheumatol. 26. 2609-2614 (1999)

M、Izumi 等人：“人类 T 细胞白血病病毒 I 相关脊髓病患者的干燥综合征 (SS)：”J Rheumatol。

M, sumi et al: "The MR imaging assessment of submandibular gland sialoadenitis associated secondary to sialolithiasis : comparison with CT and Histopathology"AJNR. 20. 1737-1743 (1999)

M, sumi 等人：“继发于唾液结石的下颌下腺唾液腺炎的 MR 成像评估：与 CT 和组织病理学的比较”AJNR。