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Assessment of let ventricular volume reduction therapy for end-stage heart failure

心室减容治疗终末期心力衰竭的评估

基本信息

批准号：
09671397
负责人：
HACHIDA Mitsuhiro
金额：
$ 1.98万
依托单位：
University of Occupational and Environmental Health (1999)Tokyo Women's Medical University (1997-1998)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671397/
关键词：
Cardiomyopathy Volume reduction therapy Oxygen consumption Wallstress Heart Transplant Artificial Heart Batista Operation

项目摘要

AbstractMechanical circulatory assist and ventricular volume reduction therapy, so called Batista operation, has been widely used as a bridge to transplantation. However, Since 1996 clinical trial for Novacor assist device has started. Since 1996, two patients have undergone Novacor implantation. One patient was supported by the device for 6 months and then received heart transplantation at UCLA. Another patients has been doing well for 2 months under Novacor device. The institute that underwent Novacor implantation is still limited number. By contrast Batista operation is widely applicable in Japan. In this study, the effect of volume reduction was assessed by experimental model.Using rabbit model, heart was excised and connected to Langendorf apparatus. The heart was arrested for 6 hours using cardioplegia and was recovered following the ischemic time. The small elastic balloon was inserted to the left ventricle and inflated upto 200% of normal volume, reducing to 100% of normal volume. During the inflation, left ventricular function such as developed pressure, left ventricular wall stress and oxygen consumption were measured. The wall stress and oxygen consumption was significantly reduced at 140% of normal left ventricular volume. These data indicated that left ventricular volume reduction therapy can be accomplished at 140% of normal left ventricular volume.

机械循环辅助和心室减容术（Batista手术）已被广泛应用于心脏移植手术。然而，自1996年以来，Novacor辅助装置的临床试验已经开始。自1996年以来，有2例患者接受了Novacor植入术。一名患者在该装置的支持下工作了6个月，然后在UCLA接受了心脏移植。另一名患者在Novacor器械下使用2个月后情况良好。进行Novacor植入的研究所数量仍然有限。相比之下，巴蒂斯塔手术在日本广泛适用。本研究通过动物实验观察心脏减容术的效果。心脏停跳6小时，缺血时间后恢复。将小的弹性球囊插入左心室，并膨胀至正常体积的200%，减少至正常体积的100%。在充气过程中，测量左室功能，如发展压力、左室壁应力和氧耗量。室壁应力和氧耗量在正常左心室容积的140%时显著降低。这些数据表明，左心室减容治疗可以在正常左心室容积的140%下完成。