Natural Killer Cell Activity and Other Immunologic Function in the Normal Elderly : an Assodiation with Infection

正常老年人的自然杀伤细胞活性和其他免疫功能:与感染的关联

• 批准号: 09670494
• 负责人: AN Emi
• 金额: $ 1.66万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670494/
• 关键词: Natural killer cell activity; Elderly; infection

We examined natural killer (NK) cell activity (lytic units, LU) and lymphocyte subsets (CD3+, CD4+, CD8+, CD25+, CD56+, CD3+HLA・DR+, CD3+CD56+ and NK [CD3-CD56+] cells) in the immunologically normal elderly. Criteria for selection were the admission criteria for immunologerontological studies (Mech Ageing Dev 1984; 28: 47-55), a performance status of World Health Organization grade 2 or 3, and informed consent. The LU of one normal subject was determined concurrently in every NK cell activity assay to ascertain the reliability of the assays. Further, the LU of this subject was defined as 100, and the relative potency of LU of the examined subjects (corrected LU, CLU) was calculated. CLU of 108 subjects (83 females; 81 yeards old [SD 8, range 63-99]) was determined. We examined whether any of the predetermined parameters related to infectious episodes during the follow-up period. A lowr CLU, age over 75 years, performance status of 3, and serum albumin value less tha 3.5 g/dl correlated with the development of infection. Multivatiate logistic regression analysis showed that a lower NK cell activity was an independent predictor for the development of infection.

我们在免疫正常的老年人中检测了自然杀伤细胞（NK）活性（溶解单位，LU）和淋巴细胞亚群（CD3+、CD4+、CD8+、CD25+、CD56+、CD3+HLA·DR+、CD3+CD56+和NK [CD3-CD56+]细胞）。选择标准是免疫学研究的入学标准（Mech Ageing Dev 1984; 28: 47-55）、世界卫生组织2级或3级的表现状况以及知情同意。每个NK细胞活性测定同时测定一个正常受试者的LU，以确定测定的可靠性。进一步将该受试者的LU定义为100，计算被试LU的相对效价（校正后的LU， CLU）。测定108例受试者（女性83例，81岁[SD 8，范围63-99]）的CLU。在随访期间，我们检查了是否有任何预先确定的参数与感染发作有关。较低的CLU、年龄大于75岁、体能状态为3、血清白蛋白值小于3.5 g/dl与感染的发生相关。多元逻辑回归分析表明，NK细胞活性降低是感染发展的独立预测因子。

项目成果

Ogata, K. et al: "Natural Killer Cells in the Late Decades of Human Life"Clinical Immunology and Immunopathology. 84 (3). 269-275 (1997)

Ogata, K. 等人：“人类生命后期几十年的自然杀伤细胞”临床免疫学和免疫病理学。

安恵美 他9名: "正常高齢者のNK細胞活性と感染症の発生・予後との関連"International Journal of HEMATOLOGY. 7/Suppl. No.1. 129 (2000)

Yasumi 等 9 人：“NK 细胞活性与正常老年人感染性疾病的发生和预后的关系”，International Journal of HEMATOLOGY 7/Suppl.129 (2000)。

安 恵美 他9名: "正常高齢者のNK細胞活性と感染症の発生・予後との関連"International Journal of HEMATOLOGY. 71suppl,No.1. 129 (2000)

Emi Yasu 等 9 人：“NK 细胞活性与正常老年人感染性疾病的发生和预后的关系”，International Journal of HEMATOLOGY，71suppl，第 1. 129 期（2000 年）。

Ogata, K. 他: "Natural killer Cells in the Late Decades of Human Life"Clinical Immunology and Immunopathology. 84(3). 269-275 (1997)

Ogata，K.等人：“人类生命晚期的自然杀伤细胞”临床免疫学和免疫病理学84(3)(1997)。

An, E. et al: "Correlation between Natural Killer Cell Function and the Development of Infection in Elders"International Journal of Hematology. 71 supol. No. 1. 129 (2000)

An, E. 等人：“自然杀伤细胞功能与老年人感染发展的相关性”国际血液学杂志。