Determinants of immune response following COVID-19 natural infection and vaccination in elderly residents of UK long term care home facilities

英国长期护理院设施老年居民 COVID-19 自然感染和疫苗接种后免疫反应的决定因素

• 批准号: 2738854
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2738854
• 关键词: Determinants; immune; response; following; COVID

Age and frailty are major determinants of outcome following COVID-19. Over 18 months our research team has acted as the hub for immunological analysis of immune responses in staff and residents of long-term care facilities (Care Homes) across the UK. This VIVALDI consortium has now acquired >15,000 blood samples which are housed within Professor Moss's research group at Birmingham.We propose a PhD training opportunity to assess the determinants of immune response in older people. This is an iCASE collaboration between University of Birmingham and The Binding Site company. This is important as immune senescence and inflammatory frailty limit the efficacy of protective immunity in older people and our aim is to identify underlying mechanisms and potential therapeutic mechanisms.The work will have five work packages.(1) Analysis of serological and cellular responses to viral proteins(2) Determination of how nutritional factors impact on immune responses(3) Assessment of inflammatory profile using novel mass spectrometry(4) Analysis of plasma cell turnover using s-BCMA assay(5) Bioinformatic analysis of these world-leading datasetsThis collaboration combines world-leading teams in academic immunology and commercial expertise in development of immune assays. The outcomes will impact on patient outcome and provide an outstanding training opportunity.

年龄和虚弱是COVID-19后结果的主要决定因素。在过去的18个月里，我们的研究团队一直是英国长期护理机构（护理之家）工作人员和居民免疫反应的免疫学分析中心。这个VIVALDI联盟现在已经获得了超过15，000份血液样本，这些样本被存放在伯明翰的Moss教授的研究小组中。我们提出了一个博士培训机会，以评估老年人免疫反应的决定因素。这是伯明翰大学和The Binding Site公司之间的iCASE合作。这一点很重要，因为免疫衰老和炎症虚弱限制了老年人保护性免疫的功效，我们的目标是确定潜在的机制和潜在的治疗机制。(1)分析对病毒蛋白的血清学和细胞反应（2）确定营养因素如何影响免疫反应（3）使用新型质谱法评估炎症特征（4）使用s-BCMA测定法分析浆细胞周转（5）对这些世界领先的抗体进行生物信息学分析这项合作结合了世界领先的学术免疫学团队和免疫测定开发方面的商业专业知识。结果将影响患者的结果，并提供出色的培训机会。