Treatment of ischemic neuropathy especially with turning point.

1999年，我们研究了血管收缩药(去甲肾上腺素、内皮素-1和血管紧张素II)对2、6和24月龄SD大鼠神经外膜小动脉血管反应性的影响。与2月龄和6月龄大鼠相比，神经血流量(NBF)减少，血管阻力(VR)增加。所有的缩窄剂都随着年龄的增长而显著减少。这些结果提示，在衰老过程中，周围神经对去甲肾上腺素、内皮素-1和血管紧张素II的收缩反应减弱，这些变化可能是由于受体功能改变所致。在缺血性神经病的治疗中，我们还必须考虑到衰老因素。

In 1999, we studied the influence of the vaso-constricting agents(noradrenaline, endothelin-1 and angiotensin II)in Sprague-Dawley rats aged 2, 6 and 24 months by evaluating epineuria arteriolar vasoreactivity in response to superfused test agents. Nerve blood flow(NBF)was decreased and vascular resistance(VR)was increased compared with 2- and 6-month-old rats. All of the constricting agents reduced significantly with age. These results suggest that during aging, there is decline of vasoconstrictive response to noradrenaline, endothelin-1 and angiotensin II in peripheral nerve and that these changes may be due to altered function of receptors. In resucue of ischemic neuropathy, we have to consider of aging factor also.