Clinico-Pathologic Study Regarding the Progressive and Aggravating Factors in Children with Chronic Renal Diseases

儿童慢性肾病进展和加重因素的临床病理研究

基本信息

批准号：
09670853
负责人：
TANIZAWA Takakuni
金额：
$ 1.09万
依托单位：
Hyogo College of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

In 1997, we established the database containing clinical laboratory data at the time of renal biopsy, renal histological changes and prognosis of 600 children from 800 renal biopsied cases.Among the chronic renal diseases discovered by annual urine screening examination at school, IgA nephropathy takes 48% by the most, congenital renal anomalies and thin basement membrane disease (TBM) follows 3.1% and 2.2%, respectively.Although urine screening at school is useful for discovering chronic glomeruloneohritides, especially for IgA nephropathy, TBM and hereditary nephritis, there is a limitation in discovery of renal diseases which need infant urinalysis or image analysis for diagnosis, such as congenital renal anomalies and reflux nephropathy.In 1998, Renal expression of alpha chain subclass of type IV collagen protein was examined in 13 children with thin basement membrane disease (TBMD) using deparaffinized sections. Although there was no cases who suffered from renal dysfunction durin … More g 6.1 years' follow-up, one male patient who showed a decreased expression of type IV collagen α 3, 4, and 5 chain protein was proved proteinuria later.As a result, immunohistological procedure of type IV collagen subclass might be a useful for discrimination of TBMD and Alport syndrome.In 1999, we examined the relationship among renal IL-6 deposition, urinary IL-6 excretion and renal pathological changes of IgA nephropathy in 12 patients.Although the significant correlation between urinary excretion and renal deposition of IL-6 has not been observed, that significant positive correlations both between renal IL-6 expression and proteinuria, and between IL-6 expression and renal pathological lesion have been proved. However, we have not found any correlation between urinary IL-6 level and renal lesion or proteinura. In particular, renal IL-6 expression closely correlated to chronic pathological changes, therefore it will be possible that renal IL-6 overdue expression could be used as a indicator of protracted course of IgA nephropathy. Less

1997年，我们在肾脏活检时，建立了包含临床实验室数据的数据库，对800例肾脏活检病例的600名儿童进行了600名儿童的预后。在年度尿液筛查在学校发现的慢性肾脏疾病中，IGA肾脏病在IGA肾脏疾病中，IGA肾脏疾病大多数，较薄的肾脏肾脏和较薄的肾脏均等范围，又有3个频率范围，又有3个频率范围，范围是频繁的季节，这些疾病是频繁的范围。分别为2.2％，分别为2.2％。尽管在学校进行尿液筛查对于发现慢性肾小球胆固醇，特别是对于Iga肾病，TBM和遗传性肾炎，在发现肾脏疾病的限制中，需要肾脏疾病，这些肾脏疾病需要婴儿的尿液分析或诸如肾小球肾脏的肾脏表达方式，例如肾脏的肾脏和肾脏含量199888。使用脱咖啡因的切片检查了13名薄基底膜疾病（TBMD）的13名儿童IV胶原蛋白的链子类。尽管没有病例患有肾功能障碍……更多的G 6.1年的随访，但一名男性患者在后来证明了IV型胶原型α3、4和5链蛋白表达下降的降低，后来证明了蛋白尿。作为结果，IV型胶原率的免疫学方法可能是对TBM的歧视的一种有用的，这是一种有用的rent rent rentrome and rent rentrome and rentrome and rentrome and rentrome。 IL-6的沉积，IL-6的沉积，IgA肾病的排泄和肾脏病理变化，尽管尚未观察到IL-6的尿极端与肾脏沉积之间的显着相关性，但尚未观察到IL-6的肾脏沉积与肾脏的正相关，肾脏IL-6表达与蛋白尿之间的显着正相关，以及IL-6表达之间的pred和肾脏的表达和肾脏的病态学。但是，我们尚未发现尿IL-6水平与肾脏病变或蛋白尿之间有任何相关性。特别是，肾脏IL-6表达与慢性病理变化密切相关，因此，肾脏IL-6逾期表达可能被用作IgA肾病的受保护过程的指标。较少的