Evaluation of newly developed heat liquid injector and its basic study

经皮无水乙醇注射疗法（PEIT）已被广泛接受用于治疗肝细胞癌（HCC）。然而，一次注射中有限体积的乙醇需要重复注射以获得足够的结果，限制了其应用于直径小于3cm的少于3个HCC结节。我们研制了一种在超声引导下安全、准确地将加热乙醇注入肿瘤结节的装置，并取得了以下结果。（1）注射乙醇的温度达到60℃、70℃时，对大鼠肝脏的坏死作用较室温时明显增强。（2）注射乙酸时，5%、20%、30%、50%组的坏死体积差异有显著性（P<0.05）。10%醋酸组在50℃、70℃和100℃下的坏死体积差异有显著性（P<0.05）。(3)It结果表明，注射加热的乙酸，即使在低浓度下也能获得强烈的坏死作用。

Percutaneous ethanol injection therapy (PEIT) has been widely accepted for the treatment of hepatocellular carcinoma (HCC). However, the limited volume of ethanol in one shot requires repeated injections to attain adequate results, restricting its application to less than 3 HCC nodules of less than 3 cm in diameter. We developed a device in which heated ethanol can be injected into tumor nodules safely and accurately under ultrasonic guidance using this device, we got the following results.(1)When the temperature of ethanol injected reached 60℃, 70℃ the necrotic effects on the rat liver were markedly increased compared to those at room temperature.(2)For injection of acetic acid, significant differences (P<0.05) were observed in volume of necrosis among groupes administered 5%, 20%, 30% and 50%. For 10% acetic acid, significant differences (P<0.05) were obseved in volume of necrosis among groups at 50℃, 70℃ and 100℃.(3)It was shown that with injection of heated acetic acid, a strong necrotizing effect was obtained even at a low concentration.